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The toxicological evaluation and histopathological findings of a long-term inhalation study in progress with N-nitrosodimethylamine (NDMA) are presented. Exposure was to three concentrations of NDMA: 0.04, 0.2 and 1.0 ppm (corresponding to 120, 600 and 3000 micrograms/m3). A significant reduction in median survival time (nine months) was seen in animals treated with the highest concentration of NDMA. Tumours occurred mainly in the nasal cavity, with the highest incidences in the groups receiving 1.0 and 0.2 ppm NDMA (19/36 and 31/36 tumour-bearing animals); in the lowest exposure group, 13/36 nasal tumours have been observed. The survival time of this treatment group, however, was about two months longer than that of the controls.
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
June 1981,
British journal of experimental pathology,
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
January 1997,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
June 2007,
Journal of toxicology and environmental health. Part A,
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
April 1984,
Cancer research,
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
December 2013,
Occupational and environmental medicine,
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
October 1992,
Bratislavske lekarske listy,
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
January 1978,
Scandinavian journal of work, environment & health,
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
April 1985,
Xenobiotica; the fate of foreign compounds in biological systems,
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
July 1991,
Biochemical pharmacology,
R G Klein, and
I Janowsky, and
B L Pool-Zobel, and
P Schmezer, and
R Hermann, and
F Amelung, and
B Spiegelhalder, and
W J Zeller
December 2003,
Inhalation toxicology,
