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Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones. 2008
Oya Bozdağ-Dündar, and
Eugen J Verspohl, and
Net Daş-Evcimen, and
Rebecca M Kaup, and
Katrin Bauer, and
Mutlu Sarikaya, and
Begüm Evranos, and
Rahmiye Ertan
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandoğan, Ankara, Turkey. bozdag@pharmacy.ankara.edu.tr
A new series of flavonyl-2,4-thiazolidinediones (Va-c, VIa-c) was prepared by Knoevenagel reaction. The synthesized compounds were tested for their ability to inhibit rat kidney aldose reductase (AR) and for their insulinotropic activities in INS-1 cells. Compound Vb was able to increase insulin release in the presence of 5.6mmol/l glucose. Compounds VIa-c displayed moderate to high AR inhibitory activity levels. Particularly, compound VIa showed the highest AR inhibitory activity (86.57%).
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