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Insulin release in the perfused isolated rat pancreas was measured after stimulation with 16.5 mM glucose with and without somatostatin (cycle form, 100 ng/ml) in the medium. A complete blockage of the typical biphasic pattern of insulin release ocurred with somatostatin in the medium. Such blockage was abolished when cAMP (2.5 mM) and a 0.5 ml solution of glucagon (1 mg/ml) were continuously perfused for 20-minute periods and for 30-second periods correspondently. It did not take place when glibenclamide (HB-419) was perfused for a 20-minute period at a rate of 10 mug/ml. The results suggest that the adenylcyclase dependent mechanisms of glucose-induced insulin release are involved in the inhibition of the glucose-induced insulin secretion by somatostatin.
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I Pagés, and
E Rodríguez, and
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F Melani
June 1983,
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I Pagés, and
E Rodríguez, and
M Marasco, and
F Melani
December 1977,
Endocrinology,
J Osorio, and
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J G de los Arcos, and
I Pagés, and
E Rodríguez, and
M Marasco, and
F Melani
July 1967,
Diabetes,
J Osorio, and
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I Pagés, and
E Rodríguez, and
M Marasco, and
F Melani
January 1982,
Peptides,
J Osorio, and
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J G de los Arcos, and
I Pagés, and
E Rodríguez, and
M Marasco, and
F Melani
November 1979,
Proceedings of the National Academy of Sciences of the United States of America,
J Osorio, and
J E Campillo, and
J G de los Arcos, and
I Pagés, and
E Rodríguez, and
M Marasco, and
F Melani
September 1980,
Diabetes,
J Osorio, and
J E Campillo, and
J G de los Arcos, and
I Pagés, and
E Rodríguez, and
M Marasco, and
F Melani
June 1974,
FEBS letters,
J Osorio, and
J E Campillo, and
J G de los Arcos, and
I Pagés, and
E Rodríguez, and
M Marasco, and
F Melani
October 1974,
The Journal of clinical investigation,
J Osorio, and
J E Campillo, and
J G de los Arcos, and
I Pagés, and
E Rodríguez, and
M Marasco, and
F Melani
January 1975,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
J Osorio, and
J E Campillo, and
J G de los Arcos, and
I Pagés, and
E Rodríguez, and
M Marasco, and
F Melani
July 1975,
FEBS letters,
