BIOMAT Database Logo BIOMAT Database Logo

Expression of cytotoxicity-associated genes in Marek's disease virus-infected chickens. 2008

Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.

Cytotoxic host responses to Marek's disease virus (MDV) have been attributed to both natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). However, the mechanisms of cell lysis initiated by these cytotoxic responses during MDV infection are not well defined. Therefore, the current study was aimed at elucidating the molecular mechanisms of host cytotoxic responses to MDV infection by investigating the expression of genes in the cell lysis pathway involving granzyme A. Genes encoding cytolytic proteins, NK lysin, and granzyme A were upregulated during early stages of infection, whereas the genes encoding major histocompatibility complex (MHC) class I and the DNA repair and apoptosis protein, poly(ADP-ribose) polymerase (PARP), were downregulated. These findings shed more light on the mechanisms of host response to MDV infection in chickens.

UI MeSH Term Description Entries
D008380 Marek Disease A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye. Fowl Paralysis,Marek's Disease,Fowl Paralyses,Mareks Disease,Paralyses, Fowl,Paralysis, Fowl
D008381 Herpesvirus 2, Gallid The type species of the genus MARDIVIRUS in the family HERPESVIRIDAE. It is the etiologic agent of MAREK DISEASE, infecting domestic fowl and wild birds. Fowl Paralysis Virus,Marek's Disease Herpesvirus 1,Marek's Disease Virus Serotype 1,Neurolymphomatosis Virus,Gallid Herpesvirus 2,Herpesvirus 2 (gamma), Gallid,Marek Disease Herpesvirus 1,Fowl Paralysis Viruses,Neurolymphomatosis Viruses,Paralysis Virus, Fowl,Paralysis Viruses, Fowl
D009088 Mucoproteins Conjugated proteins in which mucopolysaccharides are combined with proteins. The mucopolysaccharide moiety is the predominant group with the protein making up only a small percentage of the total weight.
D011065 Poly(ADP-ribose) Polymerases Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE. ADP-Ribosyltransferase (Polymerizing),Poly ADP Ribose Polymerase,Poly(ADP-Ribose) Synthase,Poly(ADP-ribose) Polymerase,PARP Polymerase,Poly ADP Ribose Transferase,Poly ADP-Ribose Synthase,Poly(ADP-Ribose) Transferase,Poly(ADPR) Polymerase,Poly(ADPribose) Polymerase,Poly ADP Ribose Synthase,Polymerase, PARP,Synthase, Poly ADP-Ribose
D002645 Chickens Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA. Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001715 Bird Diseases Diseases of birds not considered poultry, therefore usually found in zoos, parks, and the wild. The concept is differentiated from POULTRY DISEASES which is for birds raised as a source of meat or eggs for human consumption, and usually found in barnyards, hatcheries, etc. Avian Diseases,Avian Disease,Bird Disease,Disease, Avian,Disease, Bird,Diseases, Avian,Diseases, Bird
D013154 Spleen An encapsulated lymphatic organ through which venous blood filters.
D015395 Histocompatibility Antigens Class I Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells. Class I Antigen,Class I Antigens,Class I Histocompatibility Antigen,Class I MHC Protein,Class I Major Histocompatibility Antigen,MHC Class I Molecule,MHC-I Peptide,Class I Histocompatibility Antigens,Class I Human Antigens,Class I MHC Proteins,Class I Major Histocompatibility Antigens,Class I Major Histocompatibility Molecules,Human Class I Antigens,MHC Class I Molecules,MHC-I Molecules,MHC-I Peptides,Antigen, Class I,Antigens, Class I,I Antigen, Class,MHC I Molecules,MHC I Peptide,MHC I Peptides,Molecules, MHC-I,Peptide, MHC-I,Peptides, MHC-I

Related Publications

Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Expression profiling of genes associated with regulatory functions of T-cell subsets in Marek's disease virus-infected chickens.
October 2010, Avian pathology : journal of the W.V.P.A,
Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Expression of cytokine genes in Marek's disease virus-infected chickens and chicken embryo fibroblast cultures.
May 2000, Immunology,
Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Delayed hypersensitivity reactions in Marek's disease virus-infected chickens.
November 1972, American journal of veterinary research,
Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Differential expression of Toll-like receptor genes in lymphoid tissues between Marek's disease virus-infected and noninfected chickens.
March 2013, Poultry science,
Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Incidence of parvoviruses in chickens infected with Marek's disease virus.
January 2013, Polish journal of veterinary sciences,
Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Ultrastructure of tumor cells in Marek's disease virus-infected chickens.
August 1973, American journal of veterinary research,
Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Marek's disease virus-induced expression of cytokine genes in feathers of genetically defined chickens.
April 2009, Developmental and comparative immunology,
Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Demonstration of Marek's disease tumor-associated surface antigen in chickens infected with nononcogenic Marek's disease virus and herpesvirus of turkeys.
September 1978, Journal of the National Cancer Institute,
Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Immune Responses in Cecal Tonsils of Marek's Disease Virus-Infected Chickens.
June 2015, Avian diseases,
Aimie J Sarson, and Mohamed F Abdul-Careem, and Leah R Read, and Jennifer T Brisbin, and Shayan Sharif
Analysis of protein expression profiles in the thymus of chickens infected with Marek's disease virus.
November 2012, Virology journal,
Copied contents to your clipboard!