Clinical, laboratory and morphological manifestations of impaired hemostasis due to CNS bacterial infections varying in etiology were studied in 144 patients and 32 cadavers. Etiologic and age-specific features of hemocoagulatory homeostatic disorders displayed multidirectional procoagulatory, coagulatory and fibrinolytic components. Correlation of morphological evidence for the brain and viscera with clinical-laboratory findings showed that in 69% of the patients who had died of bacterial meningoencephalitis (a generalized form) there were signs of DIC syndrome. These did not always agree clinically with the picture of hemocoagulatory disturbances creating difficulties for its diagnosis. As a result, an intravital diagnosis of DIC syndrome was made in 9% of the patients only.