-transparent.png){kind=logo}
Each of creatinine (Cr), guanidinoacetic acid (GAA) and arginine (Arg) was administered intraperitoneally to rats with renal failure, and the levels of methylguanidine (MG) in the serum, liver, kidney, muscle and urine were determined at certain intervals. The levels of MG in the serum, liver, kidney, muscle and urine after Cr administration increased markedly with time. The amount of total MG at 24 h was estimated to be 114 micrograms/100 g body weight, which accounted for 0.46% of the Cr dose. In contrast, changes in MG levels after administration of GAA or Arg were only slight in comparison with those after Cr administration. Thus, MG was proved to be produced mainly from Cr.
T Yokozawa, and
N Fujitsuka, and
H Oura
January 1993,
Nephron,
T Yokozawa, and
N Fujitsuka, and
H Oura
January 1981,
Nephron,
T Yokozawa, and
N Fujitsuka, and
H Oura
December 1989,
Clinical science (London, England : 1979),
T Yokozawa, and
N Fujitsuka, and
H Oura
December 1973,
Experientia,
T Yokozawa, and
N Fujitsuka, and
H Oura
April 1968,
Experientia,
T Yokozawa, and
N Fujitsuka, and
H Oura
January 1989,
Nephron,
T Yokozawa, and
N Fujitsuka, and
H Oura
June 1971,
The Journal of laboratory and clinical medicine,
T Yokozawa, and
N Fujitsuka, and
H Oura
October 1995,
The Journal of veterinary medical science,
T Yokozawa, and
N Fujitsuka, and
H Oura
January 1972,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
T Yokozawa, and
N Fujitsuka, and
H Oura
May 1979,
Nihon Jinzo Gakkai shi,
