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A role of the free-radical processes and disturbances of oxidative-restorative blood homeostasis and nervous tissue in the pathogenesis of brain ischemic pathology and other diseases are reviewed. Attention is focused on the search for optimal ways of pharmacological correction of oxidative stress in the schemes of complex treatment of chronic blood circulation insufficiency and on the necessity of combined application of several antioxidants with different mechanisms of action which reciprocally potentiate each other. Experimental and clinical suppositions of the use of a-lipoic acid as one of the most studied antioxidant in the treatment of brain ischemia as well as the results of own studies on the preparation berlition which contains a-lipoic acid used in the neuroprotective therapy of chronic brain ischemia for correction of free-radical processes are discussed.
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
March 1994,
Neurochemistry international,
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
January 2002,
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
January 1985,
Progress in brain research,
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
January 2007,
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury,
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
July 2000,
Bulletin of experimental biology and medicine,
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
May 1988,
Neuroscience letters,
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
January 1991,
Meditsinskaia radiologiia,
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
January 2009,
Fiziologiia cheloveka,
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
March 2003,
No to shinkei = Brain and nerve,
E Iu Solov'eva, and
O P Mironova, and
O A Baranova, and
E M Bekman, and
A V Aseĭchev, and
A I Fedin, and
O A Azizova
September 2004,
Nihon rinsho. Japanese journal of clinical medicine,
