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The aim of this study was to determine the mechanisms responsible for concordant xenograft rejection using the hamster-to-rat heart graft model. Even though it was known that rat CD4 positive T cells proliferated to hamster stimulators in mixed lymphocyte reactions, the depletion of CD4 positive T cells in rat recipients did not lead to an extension of xenograft survival. Suppression of T cell immunity using other monoclonal antibodies or cyclosporine also failed to improve survival. Only by depleting complement with cobra-venom factor could hamster xenograft survival be prolonged, and long-term survival was achieved by combining CsA with COF. High-antibody titers to hamster cells were found after transplantation of hamster hearts, and evidence is presented that rejection of these "concordant" xenografts is mediated primarily by antibody-complement mechanisms. The antihamster antibodies were produced in the absence of T cell help, which suggests that antibody-mediated graft destruction cannot be inhibited by suppression or depletion of T cells. Pharmacologic depletion of complement for the clinical application of concordant xenografts is a promising avenue of future research.
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R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
September 1999,
Transplantation proceedings,
J van den Bogaerde, and
R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
February 1991,
Transplantation proceedings,
J van den Bogaerde, and
R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
January 1998,
Journal of immunology (Baltimore, Md. : 1950),
J van den Bogaerde, and
R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
May 2000,
Journal of immunology (Baltimore, Md. : 1950),
J van den Bogaerde, and
R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
January 2001,
Transplantation proceedings,
J van den Bogaerde, and
R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
November 2001,
Xenotransplantation,
J van den Bogaerde, and
R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
June 1994,
Transplantation proceedings,
J van den Bogaerde, and
R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
August 1997,
Transplantation proceedings,
J van den Bogaerde, and
R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
June 1998,
Transplantation,
J van den Bogaerde, and
R Aspinall, and
M W Wang, and
N Cary, and
S Lim, and
L Wright, and
D White
November 2008,
Fertility and sterility,
