[Pathogenetic aspects of arthrosis and its therapeutic aspects]. 1991

H G Fassbender
Zentrum für Rheuma-Pathologie (WHO Centre), Mainz.

The hitherto accepted idea that articular cartilage is merely bradythrophic tissue which, like a shoe sole, is subjected to continuous wear and tear, as a whole must be revised by considering the growing biochemical, biophysical, and ultrastructural research of the matrix components. The chondrocyte is the single living element of the cartilage: Type-II collagenous fibres and the proteoglycans are its products. To what extent the regulation of collagen production and above all the steady-state regulation is controlled by a superordinating regulation is still not known. However, we must absolutely postulate such. In the mechanics of the joint there are two antagonists which confront each other: 1. the (to a large degree) intellectually regulatable physical strain; and 2. the quality of the cartilage matrix. This represents a refined hydroelastic system. Research into the biochemistry and biophysics continuously provides an increasing abundance of new data on the molecular biological mechanisms, which 1. induce the degradation of proteoglycans and collagens; 2. increase the synthesis of the matrix components; 3. antagonize the degradation, and 4. inhibit the synthesis. In addition, an interaction of these factors can also be expected. Moreover, new information on the components and structures of the matrix is continuously gathered. Up to now, we know of 14 different types of collagen, which on the other hand are accessible to various degradative enzymes. The most important, and--from the standpoint of the biomechanics--the most interesting element/building block is, however, the proteoglycan molecule, whose excessive water-binding capacity enables the hydroelasticity of the hyaline cartilage.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D010003 Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans. Arthritis, Degenerative,Osteoarthrosis,Osteoarthrosis Deformans,Arthroses,Arthrosis,Arthritides, Degenerative,Degenerative Arthritides,Degenerative Arthritis,Osteoarthritides,Osteoarthroses
D011509 Proteoglycans Glycoproteins which have a very high polysaccharide content. Proteoglycan,Proteoglycan Type H
D002358 Cartilage, Articular A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact. Articular Cartilage,Articular Cartilages,Cartilages, Articular
D003094 Collagen A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH). Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001696 Biomechanical Phenomena The properties, processes, and behavior of biological systems under the action of mechanical forces. Biomechanics,Kinematics,Biomechanic Phenomena,Mechanobiological Phenomena,Biomechanic,Biomechanic Phenomenas,Phenomena, Biomechanic,Phenomena, Biomechanical,Phenomena, Mechanobiological,Phenomenas, Biomechanic

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