Biomaterial Database

[Effects of S-alpha-chlorohydrin on male ICR mice fertility]. 2008

Hao Zhang, and Guoqing Qian, and Xiao Ling, and Jianwei Zhao, and et al

Key laboratory of Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China. mikehootzzz@yahoo.com.cn

OBJECTIVE To study the effects of S-alpha-chlorohydrin on male ICR mice mating index, fertility index and the histopathologic changes of testis and epididymis. METHODS 64 sexually mature male ICR mice were randomly divided into four groups, each group contained 16 mice. At the doses of 1/40, 1/20 and 1/10LD50 (mice oral, LD50 117.54 mg/kg) S-alpha-chlorohydrin (ACH) were administrated consecutively by oral gavage to male ICR mice, while equal volume redistilled water was given to the controls. At the 5th day mating tests were started, and four male mice from each group were mated with females at a ratio of 1:1. The mating test was carried out every other day until 2 months, and the mating index and the male fertility index induced by S-alpha-chlorohydrin were observed. 6 male mice from each group were exposed with S-alpha-chlorohydrin for another 6 months, and then epididymal cauda sperm counts and histopathological changes in the testes and epididymides were evaluated. RESULTS (1) In Comparison with control groups, the mating index and male fertility index in male mice exposed to S-alpha-chlorohydrin for two months at any dose level were not changed; (2) There were no significant changes in cauda sperm count between treated and control groups, and no obvious histopathological injuries were observed in testes and epididymides of treated mice. CONCLUSIONS Long term exposure to S-alpha-chlorohydrin less than 1/40LD50 did not induce antifertility effects in male ICR mice.

UI	MeSH Term	Description	Entries
D007248	Infertility, Male	The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.	Sterility, Male,Sub-Fertility, Male,Subfertility, Male,Male Infertility,Male Sterility,Male Sub-Fertility,Male Subfertility,Sub Fertility, Male
D007536	Isomerism	The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)	Isomerisms
D008297	Male		Males
D008813	Mice, Inbred ICR	An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER.	Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D000517	alpha-Chlorohydrin	A chlorinated PROPANEDIOL with antifertility activity in males used as a chemosterilant in rodents.	alpha-Chlorhydrin,3-Chloro-1,2-propanediol,3-Chloropropanediol,3-MCPD,3-Monochloropropane-1,2-diol,Glycerol alpha-Monochlorohydrin,U-5897,3 Chloro 1,2 propanediol,3 Chloropropanediol,3 Monochloropropane 1,2 diol,Glycerol alpha Monochlorohydrin,U 5897,U5897,alpha Chlorhydrin,alpha Chlorohydrin,alpha-Monochlorohydrin, Glycerol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013094	Spermatozoa	Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.	Sperm,Spermatozoon,X-Bearing Sperm,X-Chromosome-Bearing Sperm,Y-Bearing Sperm,Y-Chromosome-Bearing Sperm,Sperm, X-Bearing,Sperm, X-Chromosome-Bearing,Sperm, Y-Bearing,Sperm, Y-Chromosome-Bearing,Sperms, X-Bearing,Sperms, X-Chromosome-Bearing,Sperms, Y-Bearing,Sperms, Y-Chromosome-Bearing,X Bearing Sperm,X Chromosome Bearing Sperm,X-Bearing Sperms,X-Chromosome-Bearing Sperms,Y Bearing Sperm,Y Chromosome Bearing Sperm,Y-Bearing Sperms,Y-Chromosome-Bearing Sperms
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus