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Fluorescent probes and labels for biomedical applications. 2008
Leonid Patsenker, and
Anatoliy Tatarets, and
Olga Kolosova, and
Olena Obukhova, and
Yevgeniy Povrozin, and
Iryna Fedyunyayeva, and
Inna Yermolenko, and
Ewald Terpetschnig
State Scientific Institution Institute for Single Crystals of the National Academy of Sciences of Ukraine, 60 Lenin Ave., 61001 Kharkov, Ukraine. patsenker@isc.kharkov.com
Fluorescence probes and labels have become indispensable tools for clinical diagnostics, high-throughput screening, and other biomedical applications. We have developed several classes of new squaraine-based red and near-infrared (NIR) probes and labels (SETA and Square series), naphthalimide-based fluorescence lifetime dyes (SeTau series), and cyanine- and squaraine-based quenchers (SQ series). This report discusses the spectral and photophysical properties of these new markers. In particular, the red and NIR dyes of the SETA and Square series are extremely bright, with photostabilities that are unmatched by any other dyes in the same spectral region.
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