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Twenty-nine synovial fluids from patients with rheumatoid arthritis (RA) and 10 synovial fluids from patients with other joint diseases were investigated with regard to the presence of antibodies to denatured human collagen and of collagen-anticollagen immune complexes. 12 of the 29 RA synovial fluids showed anticollagen titres from 1:16 to 1:512 in passive haemagglutination. Only one patient in the group with no arthritis had a significant anticollagen titre of 1:32. Digestion of the synovial fluids with bacterial collagenase resulted in an anticollagen titre increase from two to four dilution steps in 9 of the RA fluids, while 6 previously negative RA synovial fluids showed anticollagen titres from 1:32 to 1:28 after digestion with collagenase. These results indicate the existence of collagen-anticollagen immune complexes in 15 of the 29 RA synovial fluids investigated.
J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
January 1975,
Zeitschrift fur Rheumatologie,
J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
August 1974,
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie,
J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
December 1984,
Arthritis and rheumatism,
J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
November 1984,
Arthritis and rheumatism,
J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
May 1988,
Annals of allergy,
J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
February 1983,
Arthritis and rheumatism,
J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
May 1979,
Arthritis and rheumatism,
J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
August 1975,
The Journal of clinical investigation,
J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
January 1970,
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J Menzel, and
C Steffen, and
G Kolarz, and
G Eberal, and
O Frank, and
N Thumb
September 1976,
Zeitschrift fur Immunitatsforschung. Immunobiology,
