Biomaterial Database

Urate transport across the apical membrane of renal proximal tubules. 2008

Hitoshi Endou, and Naohiko Anzai

Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan. endouh@kyorin-u.ac.jp

Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to urate transport have been identified. In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Elucidation of urate transportsome will lead to the new drug development for hyperuricemia.

UI	MeSH Term	Description	Entries
D007687	Kidney Tubules, Proximal	The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.	Proximal Kidney Tubule,Proximal Renal Tubule,Kidney Tubule, Proximal,Proximal Kidney Tubules,Proximal Renal Tubules,Renal Tubule, Proximal,Renal Tubules, Proximal,Tubule, Proximal Kidney,Tubule, Proximal Renal,Tubules, Proximal Kidney,Tubules, Proximal Renal
D008565	Membrane Proteins	Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.	Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D002352	Carrier Proteins	Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes.	Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D002462	Cell Membrane	The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.	Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014527	Uric Acid	An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.	2,6,8-Trihydroxypurine,Ammonium Acid Urate,Monosodium Urate,Monosodium Urate Monohydrate,Potassium Urate,Sodium Acid Urate,Sodium Acid Urate Monohydrate,Sodium Urate,Sodium Urate Monohydrate,Trioxopurine,Urate,Acid Urate, Ammonium,Acid Urate, Sodium,Acid, Uric,Monohydrate, Monosodium Urate,Monohydrate, Sodium Urate,Urate Monohydrate, Monosodium,Urate Monohydrate, Sodium,Urate, Ammonium Acid,Urate, Monosodium,Urate, Potassium,Urate, Sodium,Urate, Sodium Acid
D050611	Sodium-Phosphate Cotransporter Proteins, Type III	A family of highly conserved and widely expressed sodium-phosphate cotransporter proteins. They are electrogenic sodium-dependent transporters of phosphate that were originally identified as retroviral receptors in HUMANS and have been described in yeast and many other organisms.	Type III Sodium-Phosphate Cotransporter Proteins,Amphoteric Virus Receptor GLVR-2,Amphotropic MuLV Receptor,Amphotropic Murine Leukemia Virus Receptor,GLVR-2 Receptor,GLVR1 Transporter Proteins,NPT1 Protein,Pit1 Sodium-Dependent Phosphate Symporter,Pit1 Sodium-Phosphate Cotransporter,Pit2 Sodium-Dependent Phosphate Symporter,Pit2 Sodium-Phosphate Cotransporter,Ram-1 Receptor,SLC20A1 Transporter,Solute Carrier Family 20 (Phosphate Transporter), Member 1,Solute Carrier Family 20 (Phosphate Transporter), Member 2,Type III Na-Dependent Phosphate Cotransporter,Type III Sodium-Phosphate Symporter Proteins,Amphoteric Virus Receptor GLVR 2,Cotransporter, Pit1 Sodium-Phosphate,Cotransporter, Pit2 Sodium-Phosphate,GLVR 2 Receptor,MuLV Receptor, Amphotropic,Pit1 Sodium Dependent Phosphate Symporter,Pit1 Sodium Phosphate Cotransporter,Pit2 Sodium Dependent Phosphate Symporter,Pit2 Sodium Phosphate Cotransporter,Ram 1 Receptor,Receptor, Ram-1,Sodium Phosphate Cotransporter Proteins, Type III,Sodium-Phosphate Cotransporter, Pit1,Sodium-Phosphate Cotransporter, Pit2,Transporter Proteins, GLVR1,Type III Na Dependent Phosphate Cotransporter,Type III Sodium Phosphate Cotransporter Proteins,Type III Sodium Phosphate Symporter Proteins
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D027361	Organic Anion Transporters	Proteins involved in the transport of organic anions. They play an important role in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body.	Membrane Transport Proteins, Organic Anion,OAT Transport Protein,OATP Transporter,Organic Anion Transport Polypeptide,Organic Anion Transport Polypeptides,Organic Anion Transport Protein,Organic Anion Transporter,OAT Transport Proteins,OATP Proteins,OATP Transporters,Organic Anion Transport Proteins,Anion Transporter, Organic,Anion Transporters, Organic,Protein, OAT Transport,Transport Protein, OAT,Transport Proteins, OAT,Transporter, OATP,Transporter, Organic Anion,Transporters, OATP,Transporters, Organic Anion