[Tuberculosis of the larynx, oral cavity and pharynx]. 1991

T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
Abteilung Innere Medizin mit Schwerpunkt Infektionskrankheiten, Freien Universität Berlin.

A 44-year-old man, a heavy smoker over many years, complained of hoarseness for 8 weeks with weight loss and dysphagia. Malignant tumour of the pharynx was suspected. Examination revealed a swelling of the right upper lip, tumorous changes in the right buccal mucosa, about 6 x 6 cm in size, as well as enlargement of the cervical lymph-nodes. Microlaryngoscopy revealed a three-level tumour of the entire side of the right larynx. Histological examination of biopsies of the right false and true vocal cords as well as the buccal mucosa demonstrated numerous, partly caseous epithelioid granulomas with Langhans giant cells. Ziehl-Neelsen staining showed acid-fast rods. Combined tuberculostatic treatment with isoniazid, rifampicin, ethambutol and pyrazinamide achieved regression of all signs and symptoms within two months. This case emphasizes the need for including laryngeal tuberculosis in the differential diagnosis of seemingly malignant laryngeal tumours.

UI MeSH Term Description Entries
D007538 Isoniazid Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. Isonicotinic Acid Hydrazide,Ftivazide,Isonex,Isonicotinic Acid Vanillylidenehydrazide,Phthivazid,Phthivazide,Tubazide,Acid Vanillylidenehydrazide, Isonicotinic,Hydrazide, Isonicotinic Acid,Vanillylidenehydrazide, Isonicotinic Acid
D008297 Male Males
D010608 Pharyngeal Diseases Pathological processes involving the PHARYNX. Diseases of Pharynx,Pharynx Diseases,Disease, Pharyngeal,Disease, Pharynx,Diseases, Pharyngeal,Diseases, Pharynx,Pharyngeal Disease,Pharynx Disease
D010610 Pharyngeal Neoplasms Tumors or cancer of the PHARYNX. Cancer of Pharynx,Pharyngeal Cancer,Cancer of the Pharynx,Neoplasms, Pharyngeal,Neoplasms, Pharynx,Pharnyx Cancer,Pharynx Neoplasms,Cancer, Pharnyx,Cancer, Pharyngeal,Cancers, Pharnyx,Cancers, Pharyngeal,Neoplasm, Pharyngeal,Neoplasm, Pharynx,Pharnyx Cancers,Pharyngeal Cancers,Pharyngeal Neoplasm,Pharynx Cancer,Pharynx Cancers,Pharynx Neoplasm
D011718 Pyrazinamide A pyrazine that is used therapeutically as an antitubercular agent. Tisamid
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D004724 Endoscopy Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body. Endoscopic Surgical Procedures,Surgical Procedures, Endoscopic,Endoscopic Surgical Procedure,Endoscopy, Surgical,Surgical Endoscopy,Surgical Procedure, Endoscopic,Procedure, Endoscopic Surgical,Procedures, Endoscopic Surgical
D004977 Ethambutol An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863) Dexambutol,EMB-Fatol,EMB-Hefa,Etambutol Llorente,Ethambutol Hydrochloride,Etibi,Miambutol,Myambutol,EMB Fatol,EMB Hefa,Hydrochloride, Ethambutol,Llorente, Etambutol
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
October 1991, Deutsche medizinische Wochenschrift (1946),
T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
January 1950, Vestnik otorinolaringologii,
T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
June 1980, Problemy tuberkuleza,
T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
September 2016, European annals of otorhinolaryngology, head and neck diseases,
T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
January 1979, Zhurnal ushnykh, nosovykh i gorlovykh boleznei = The journal of otology, rhinology, and laryngologie [sic],
T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
August 1990, HNO,
T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
January 1971, JAMA,
T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
January 2004, Epidemiologia e prevenzione,
T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
September 2008, Presse medicale (Paris, France : 1983),
T Held, and W Rössler, and A Reichelt, and M Mielke, and M Alexander
October 1968, American journal of surgery,
Copied contents to your clipboard!