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Three ACNU-resistant sublines (R1, R3 and R12) from rat glioma 9L cells showed cross-resistance to vinblastine, adriamycin, and VP-16. Among these, the R3 subline also acquired radioresistance under aerobic conditions. Total glutathione levels in these sublines were elevated 2- to 3-fold. Treatment of the cells with BSO, a specific inhibitor of GSH synthesis, resulted in decreased intracellular total glutathione levels in all 4 cell lines to about 10% of control levels. However, sensitivity to radiation or to chemicals did not change accordingly. Treatment of 9L cells with OTZ, a precursor of cysteine, resulted in a rise in intracellular GSH levels but it did not correlate with sensitivity to X-ray or to ACNU. These results suggest that, in terms of cellular sensitivity to radiation or ACNU, total glutathione level alone cannot serve as a predictive indicator.
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
January 1987,
Journal of neuro-oncology,
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
August 1984,
No shinkei geka. Neurological surgery,
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
September 1986,
Gan to kagaku ryoho. Cancer & chemotherapy,
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
September 1992,
Journal of neurosurgery,
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
February 1987,
No shinkei geka. Neurological surgery,
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
November 1986,
No to shinkei = Brain and nerve,
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
January 1989,
Drug metabolism reviews,
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
October 1986,
No shinkei geka. Neurological surgery,
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
September 1993,
Journal of neuro-oncology,
Y Saito, and
Y Nakada, and
T Hotta, and
T Mikami, and
K Kurisu, and
K Yamada, and
K Kiya, and
K Kawamoto, and
T Uozumi
March 1987,
No shinkei geka. Neurological surgery,
