Biomaterial Database

[Ocular neuromyotonia after radiation therapy]. 2009

M van Waveren, and V Herzau, and D Besch

Sektion für Motilitätsstörungen, periokuläre Chirurgie und Kinderophthalmologie, Universitäts-Augenklinik, Tübingen, Deutschland.

Ocular neuromyotonia is a rare disease that is diagnosed mainly in patients treated with radiation. All such patients described in the literature presented with temporary diplopic images as a common symptom. In our case, the patient described an abducens paresis of the right eye combined with a sporadic exotropia half a year after radiation treatment of an epipharynx carcinoma. An adduction deficit on the right side could be triggered by holding the gaze to the right over a longer period of time, leading to exotropia in the primary position and gaze to the left. Symptoms were reduced with carbamazepine.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011832	Radiation Injuries	Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.	Radiation Sickness,Radiation Syndrome,Injuries, Radiation,Injury, Radiation,Radiation Injury,Radiation Sicknesses,Radiation Syndromes,Sickness, Radiation,Sicknesses, Radiation,Syndrome, Radiation,Syndromes, Radiation
D004172	Diplopia	A visual symptom in which a single object is perceived by the visual cortex as two objects rather than one. Disorders associated with this condition include REFRACTIVE ERRORS; STRABISMUS; OCULOMOTOR NERVE DISEASES; TROCHLEAR NERVE DISEASES; ABDUCENS NERVE DISEASES; and diseases of the BRAIN STEM and OCCIPITAL LOBE.	Double Vision,Polyopsia,Diplopia, Cortical,Diplopia, Horizontal,Diplopia, Intermittent,Diplopia, Monocular,Diplopia, Refractive,Diplopia, Unilateral,Diplopia, Vertical,Cortical Diplopia,Cortical Diplopias,Diplopias,Diplopias, Cortical,Diplopias, Horizontal,Diplopias, Intermittent,Diplopias, Monocular,Diplopias, Refractive,Diplopias, Unilateral,Diplopias, Vertical,Horizontal Diplopia,Horizontal Diplopias,Intermittent Diplopia,Intermittent Diplopias,Monocular Diplopia,Monocular Diplopias,Polyopsias,Refractive Diplopia,Refractive Diplopias,Unilateral Diplopia,Unilateral Diplopias,Vertical Diplopia,Vertical Diplopias,Vision, Double
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D020266	Radiotherapy, Conformal	A therapy using IONIZING RADIATION where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.	Conformal Radiotherapy,3-D Conformal Radiotherapy,Three-Dimensional Conformal Radiotherapy,3-D Conformal Radiotherapies,Conformal Radiotherapies,Conformal Radiotherapies, 3-D,Conformal Radiotherapies, Three-Dimensional,Conformal Radiotherapy, 3-D,Conformal Radiotherapy, Three-Dimensional,Radiotherapies, 3-D Conformal,Radiotherapies, Conformal,Radiotherapies, Three-Dimensional Conformal,Radiotherapy, 3-D Conformal,Radiotherapy, Three-Dimensional Conformal,Three Dimensional Conformal Radiotherapy,Three-Dimensional Conformal Radiotherapies
D020386	Isaacs Syndrome	A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)	Myokymia, Continuous,Neuromyotonia,Pseudomyotonia,Acquired Neuromyotonia,Continuous Muscle Activity Syndrome,Gamstorp-Wohlfart Syndrome,Isaacs' Syndrome,Isaacs-Mertens Syndrome,Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis,Pseudomyotonia Syndrome of Isaacs,Quantal Squander,Syndrome of Continuous Muscle Activity,Continuous Myokymia,Continuous Myokymias,Gamstorp Wohlfart Syndrome,Isaac Syndrome,Isaacs Mertens Syndrome,Isaacs Pseudomyotonia Syndrome,Myokymias, Continuous,Neuromyotonia, Acquired
D020434	Abducens Nerve Diseases	Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.	Abducens Palsy, Childhood, Benign Recurrent,Cranial Nerve VI Diseases,Lateral Rectus Palsy,Sixth Cranial Nerve Disorders,6th Nerve Palsy,Abducens Nerve Palsy,Abducens Palsy,Benign Recurrent Abducens Palsy of Childhood,Benign Recurrent Abducens Palsy, Children,Cranial Nerve VI Palsy,Sixth Cranial Nerve Diseases,Sixth Cranial Nerve Palsy,Sixth Nerve Palsy,VI Nerve Palsy,VIth Cranial Nerve Diseases,6th Nerve Palsies,Abducens Nerve Disease,Abducens Nerve Palsies,Abducens Palsies,Lateral Rectus Palsies,Palsies, 6th Nerve,Palsies, Abducens,Palsies, Abducens Nerve,Palsies, Lateral Rectus,Palsies, Sixth Nerve,Palsies, VI Nerve,Palsy, 6th Nerve,Palsy, Abducens,Palsy, Abducens Nerve,Palsy, Lateral Rectus,Palsy, Sixth Nerve,Palsy, VI Nerve,Sixth Nerve Palsies