-transparent.png){kind=logo}
The primary structure of 5.8S mouse ribosomal RNA has been studied and compared to the structures previously established for other animal species. The results obtained show that mouse 5.8S ribosomal RNA yields pancreatic oligonucleotides with the same nucleotide sequence as the homologous oligonucleotides from rat cells. Furthermore T1 oligonucleotides of 5.8S ribosomal RNA from rat, mouse and human cells behave identically on fingerprinting fractionation and have the same composition as judged by pancreatic digestion. These results strongly suggest that the primary structures of 5.8S ribosomal RNA from rat, mouse and human cells are identical. This identity of structure is also found when the presence of several modified bases (psi and methylated bases) is considered. The findings emphasize the remarkable evolutionary stability of ribosomal gene structure. Comparison of the terminal regional of 5.8S RNA with those of 18S RNA reveals differences which imply a more complex mechanism underlying the maturation of 45S precursor RNA than the finding of identical structure would have suggested.
A Hampe, and
M E Eladari, and
F Galibert
February 1992,
Nucleic acids research,
A Hampe, and
M E Eladari, and
F Galibert
November 1987,
Nucleic acids research,
A Hampe, and
M E Eladari, and
F Galibert
March 1982,
Nucleic acids research,
A Hampe, and
M E Eladari, and
F Galibert
February 1976,
Biochemistry,
A Hampe, and
M E Eladari, and
F Galibert
January 1987,
Molecular and biochemical parasitology,
A Hampe, and
M E Eladari, and
F Galibert
October 1991,
Nucleic acids research,
A Hampe, and
M E Eladari, and
F Galibert
March 1976,
Nature,
A Hampe, and
M E Eladari, and
F Galibert
May 1982,
Nucleic acids research,
A Hampe, and
M E Eladari, and
F Galibert
February 1975,
Biochemical and biophysical research communications,
