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Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase. 2008
Zachary K Sweeney, and
Sahaja Acharya, and
Andrew Briggs, and
James P Dunn, and
Todd R Elworthy, and
Jennifer Fretland, and
Anthony M Giannetti, and
Gabrielle Heilek, and
Yu Li, and
Ann C Kaiser, and
Michael Martin, and
Y David Saito, and
Mark Smith, and
Judy M Suh, and
Steven Swallow, and
Jeffrey Wu, and
Julie Q Hang, and
Amy S Zhou, and
Klaus Klumpp
Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. zachary.sweeney@roche.com
Novel non-nucleoside inhibitors of HIV-RT that contain pyridazinone isosteres were prepared, and a series of triazolinones were found to be potent inhibitors of HIV replication. These compounds were active against several NNRTI-resistant virus strains. Pharmacokinetic studies indicated that inhibitor 7e has good bioavailability in rats. Several fragments of inhibitor 7c were prepared, and the binding of these compounds to HIV-RT was analyzed by surface plasmon resonance spectroscopy.
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James P Dunn, and
Todd R Elworthy, and
Jennifer Fretland, and
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Ann C Kaiser, and
Michael Martin, and
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Mark Smith, and
Judy M Suh, and
Steven Swallow, and
Jeffrey Wu, and
Julie Q Hang, and
Amy S Zhou, and
Klaus Klumpp
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Todd R Elworthy, and
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Yu Li, and
Ann C Kaiser, and
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Mark Smith, and
Judy M Suh, and
Steven Swallow, and
Jeffrey Wu, and
Julie Q Hang, and
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Klaus Klumpp
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Yu Li, and
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Steven Swallow, and
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Julie Q Hang, and
Amy S Zhou, and
Klaus Klumpp
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Yu Li, and
Ann C Kaiser, and
Michael Martin, and
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Steven Swallow, and
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Julie Q Hang, and
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Klaus Klumpp
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ACS medicinal chemistry letters,
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Klaus Klumpp
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Bioorganic & medicinal chemistry letters,
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Yu Li, and
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Y David Saito, and
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Steven Swallow, and
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Klaus Klumpp
June 2000,
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Gabrielle Heilek, and
Yu Li, and
Ann C Kaiser, and
Michael Martin, and
Y David Saito, and
Mark Smith, and
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Steven Swallow, and
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Sahaja Acharya, and
Andrew Briggs, and
James P Dunn, and
Todd R Elworthy, and
Jennifer Fretland, and
Anthony M Giannetti, and
Gabrielle Heilek, and
Yu Li, and
Ann C Kaiser, and
Michael Martin, and
Y David Saito, and
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Steven Swallow, and
Jeffrey Wu, and
Julie Q Hang, and
Amy S Zhou, and
Klaus Klumpp
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European journal of medicinal chemistry,
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Sahaja Acharya, and
Andrew Briggs, and
James P Dunn, and
Todd R Elworthy, and
Jennifer Fretland, and
Anthony M Giannetti, and
Gabrielle Heilek, and
Yu Li, and
Ann C Kaiser, and
Michael Martin, and
Y David Saito, and
Mark Smith, and
Judy M Suh, and
Steven Swallow, and
Jeffrey Wu, and
Julie Q Hang, and
Amy S Zhou, and
Klaus Klumpp
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Current opinion in investigational drugs (London, England : 2000),
