[Influence of chronic exposure to heavy metals on eyesight]. 2008

Małgorzata Mulak, and Marta Misiuk-Hojło, and Bartłomiej Markuszewski, and Karolina Dembska
Katedry i Kliniki Okulistyki Akademii Medycznej we Wrocławiu.

OBJECTIVE The aim of the study was to investigate relationship between chronic occupational exposure to heavy metals and eyesight, with particular lead influence. METHODS The experimental group was composed of 120 workers of Copper Steelwork Plant "Legnica", divided into 2 groups, based on the degree and period of exposure to heavy metals. 75 men hired in direct production with work residency of 7 to 34 years (mean 21.2) made the experimental Group A--the occupationally exposed group. Group B with 45 white-collar men with work residency of 4 to 39 years (mean 19.8) made the environmentally exposed group. All workers underwent complex ophthalmic examination with particular lens investigation following pupil dilation, lead and cadmium level in full blood determination and free erythrocyte protoporphyrin (FEP) test, as indicator of human body lead overload. RESULTS Mean lead levels in both groups were considerably higher than permissible concentration in biological material (PCB) for occupationally exposed workers, and was higher for those working directly in production. Free erythrocyte protoporphyrin (FEP) level was correct in both groups. Lenticular changes were noticed in 26 (21.7%) patients, of whom 18 (69.2%) were hired in direct production. Similarly, fundus changes were shown in 17 patients, 16 (22%) from Group A; changes in field of vision in 3 patients. Furthermore, 15 men working in direct production complained of burning sensation, tearing and periodic redness in the eyes. CONCLUSIONS Mean blood cadmium and lead levels, higher in occupationally exposed workers was statistically important only in case of lead. However, the correct FEP level indicates that an organism was not overload with lead. In these workers (group A) lenticular changes were observed more often and were more intense (cortex opacitates, posterior subcapsular cataract). Fundus changes noticed in both groups were of low degree and coexisting diseases may have promoted their progression. Field of vision changes noticed in 3 workers may have been caused by lead toxicity to optic nerve. Periodical conjuctival inflammatory states are caused by irritative dust and smoke therefore protective eye wear is indicated.

UI MeSH Term Description Entries
D008297 Male Males
D008669 Metallurgy The science, art, or technology dealing with processes involved in the separation of metals from their ores, the technique of making or compounding the alloys, the techniques of working or heat-treating metals, and the mining of metals. It includes industrial metallurgy as well as metallurgical techniques employed in the preparation and working of metals used in dentistry, with special reference to orthodontic and prosthodontic appliances. (From Jablonski, Dictionary of Dentistry, 1992, p494) Heavy Industries,Industries, Heavy,Heavy Industry,Industry, Heavy
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009784 Occupational Diseases Diseases caused by factors involved in one's employment. Diseases, Occupational,Occupational Illnesses,Disease, Occupational,Illnesse, Occupational,Illnesses, Occupational,Occupational Disease,Occupational Illnesse
D011044 Poland A country in central Europe, east of Germany. The capital is Warsaw. Polish People's Republic,Republic of Poland
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D004784 Environmental Monitoring The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment. Monitoring, Environmental,Environmental Surveillance,Surveillance, Environmental
D004906 Erythrocyte Count The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD. Blood Cell Count, Red,Erythrocyte Number,Red Blood Cell Count,Count, Erythrocyte,Counts, Erythrocyte,Erythrocyte Counts,Erythrocyte Numbers
D004909 Erythrocyte Indices ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC). Erythrocyte Hemoglobin, Mean Cell,Erythrocyte Size Determination,Erythrocyte Volume, Mean Cell,Hemoglobin, Erythrocyte, Mean Cell,Mean Corpuscular Volume,Red Cell Indices,Erythrocyte Diameter,Erythrocyte Index,Erythrocyte Indexes,Erythrocyte Thickness,Mean Cell Hemoglobin Concentration,Mean Cell Volume,Mean Corpuscular Hemoglobin,Mean Corpuscular Hemoglobulin Concentration,Red Cell Distribution Width,Red Cell Index,Red Cell Indexes,Cell Volumes, Mean,Corpuscular Volumes, Mean,Determination, Erythrocyte Size,Determinations, Erythrocyte Size,Diameter, Erythrocyte,Diameters, Erythrocyte,Erythrocyte Diameters,Erythrocyte Size Determinations,Hemoglobin, Mean Corpuscular,Hemoglobins, Mean Corpuscular,Index, Erythrocyte,Index, Red Cell,Indexes, Erythrocyte,Indexes, Red Cell,Indices, Erythrocyte,Indices, Red Cell,Mean Cell Volumes,Mean Corpuscular Hemoglobins,Mean Corpuscular Volumes,Size Determination, Erythrocyte,Size Determinations, Erythrocyte,Thickness, Erythrocyte,Volume, Mean Cell,Volume, Mean Corpuscular,Volumes, Mean Cell,Volumes, Mean Corpuscular
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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