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Microtubule organization during human parthenogenesis. 2009
Yukihiro Terada, and
Hisataka Hasegawa, and
Tomohisa Ugajin, and
Takashi Murakami, and
Nobuo Yaegashi, and
Kunihiro Okamura
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan. terada@mail.tains.tohoku.ac.jp
In human fertilization, the sperm centrosome plays a crucial role as a microtubule organizing center (MTOC). We studied microtubule organization during human parthenogenesis, which occurs when a human egg undergoes cleavage without a sperm centrosome. Multiple cytoplasmic asters were organized in the human oocyte after parthenogenetic activation, indicating that multiple MTOC are present in the human oocyte cytoplasm and function like a human sperm centrosome during parthenogenesis.
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