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A patient with watery diarrhea, hypokalemia, hypochlorhydria, and a non-beta islet cell carcinoma of the pancreas (Verner-Morrison syndrome) was found to have an elevated vasoactive intestinal peptide (VIP) concentration in the plasma as well as in the tumor. Treatment with streptozocin resulted in a dramatic subjective and objective tumor response in this patient. Plasma VIP concentration fell into the normal range after four courses of treatment, diarrhea ceased after the third course of therapy, and measurable tumor mass markedly decreased during that same period of time. The patient remains in clinical remission with no evidence of tumor regrowth 18 months after the beginning of treatment. In this patient, plasma VIP measurements were an excellent marker of tumor activity and correlated well with objective disease measurements and clinical response.
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
May 1975,
Gut,
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
January 1979,
Scandinavian journal of gastroenterology. Supplement,
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
April 1979,
La Nouvelle presse medicale,
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
June 1981,
Minerva medica,
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
March 1979,
Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille,
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
January 2005,
Mayo Clinic proceedings,
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
October 1981,
Ugeskrift for laeger,
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
May 1975,
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen,
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
January 1976,
Clinical endocrinology,
R F Gagel, and
M E Costanza, and
R A DeLellis, and
R A Norton, and
S R Bloom, and
H H Miller, and
A Ucci, and
L Nathanson
June 1977,
L'union medicale du Canada,
