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1. Purified myelin was incubated with snake venom or phospholipase A in the presence of or absence of trypsin at 37 degrees C, pH7.4, for different times. 2. Analysis of the myelin pellet obtained after centrifugation of the myelin sample incubated with snake venom or phospholipase A alone showed conversion of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine into their corresponding lyso compounds. No significant loss of myelin protein was observed in these samples. 3. A marked digestion of basic proteins and proteolipid protein was observed from the myelin pellet when trypsin was present in the incubation mixture. 4. The digestion of basic protein and particularly of proteolipid from myelin suggest that phospholipases may make protein more exposed to proteolytic enzyme for its digestion. 5. The relevance of the co-operative effect of phospholipases and proteinases as a model system of the mechanism of myelin breakdown in degenerative brain diseases is discussed.
N L Banik, and
K Gohil, and
A N Davison
December 1966,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
N L Banik, and
K Gohil, and
A N Davison
January 1981,
Toxicon : official journal of the International Society on Toxinology,
N L Banik, and
K Gohil, and
A N Davison
December 1964,
Comptes rendus hebdomadaires des seances de l'Academie des sciences,
N L Banik, and
K Gohil, and
A N Davison
November 1973,
Biochimica et biophysica acta,
N L Banik, and
K Gohil, and
A N Davison
May 1984,
Biochimica et biophysica acta,
N L Banik, and
K Gohil, and
A N Davison
August 1970,
Patologia polska,
N L Banik, and
K Gohil, and
A N Davison
October 1958,
Biochimica et biophysica acta,
N L Banik, and
K Gohil, and
A N Davison
February 1962,
The Japanese journal of experimental medicine,
N L Banik, and
K Gohil, and
A N Davison
July 1954,
The Biochemical journal,
N L Banik, and
K Gohil, and
A N Davison
July 1995,
Biochimica et biophysica acta,
