BIOMAT Database Logo BIOMAT Database Logo

[Effect of N-6 2'-O-dibutyryl adenosine 3'-5'monophosphate (dibutyryl cyclic AMP) on the condenstion of the X chromosome into the form of a Barr body]. 1976

A Tumba, and E Vamos-Hurwitz

Addition of exogen DB-c AMP in medium of human fibroblasts culture, with 46 XX karyotypes, enables us to observe a high frequency of Barr bodies, about 80 or 85%. This observation suggests that the condensation of the X chromosome in the form of Barr bodies depends on the level of endogen cyclic AMP.

UI MeSH Term Description Entries
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D003994 Bucladesine A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed) Dibutyryl Adenosine-3',5'-Monophosphate,Dibutyryl Cyclic AMP,(But)(2) cAMP,Bucladesine, Barium (1:1) Salt,Bucladesine, Disodium Salt,Bucladesine, Monosodium Salt,Bucladesine, Sodium Salt,DBcAMP,Dibutyryl Adenosine 3,5 Monophosphate,N',O'-Dibutyryl-cAMP,N(6),0(2')-Dibutyryl Cyclic AMP,AMP, Dibutyryl Cyclic,Adenosine-3',5'-Monophosphate, Dibutyryl,Cyclic AMP, Dibutyryl,Dibutyryl Adenosine 3',5' Monophosphate,Disodium Salt Bucladesine,Monosodium Salt Bucladesine,N',O' Dibutyryl cAMP,Sodium Salt Bucladesine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012728 Sex Chromatin In the interphase nucleus, a condensed mass of chromatin representing an inactivated X chromosome. Each X CHROMOSOME, in excess of one, forms sex chromatin (Barr body) in the mammalian nucleus. (from King & Stansfield, A Dictionary of Genetics, 4th ed) Barr Bodies,Chromatin, Sex,Bodies, Barr,Chromatins, Sex,Sex Chromatins
D012730 Sex Chromosomes The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed) Gonosomes,Chromosome, Sex,Chromosomes, Sex,Gonosome,Sex Chromosome
D013806 Theophylline A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP. 1,3-Dimethylxanthine,3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione,Accurbron,Aerobin,Aerolate,Afonilum Retard,Aquaphyllin,Armophylline,Bronchoparat,Bronkodyl,Constant-T,Elixophyllin,Euphylong,Glycine Theophyllinate,Lodrane,Monospan,Nuelin,Nuelin S.A.,Quibron T-SR,Slo-Phyllin,Somophyllin-T,Sustaire,Synophylate,Theo Von Ct,Theo-24,Theo-Dur,Theobid,Theocin,Theoconfin Continuous,Theodur,Theolair,Theolix,Theon,Theonite,Theopek,Theophylline Anhydrous,Theophylline Sodium Glycinate,Theospan,Theostat,Theovent,Uniphyl,Uniphyllin,Uniphylline,1,3 Dimethylxanthine,Anhydrous, Theophylline,Constant T,ConstantT,Ct, Theo Von,Glycinate, Theophylline Sodium,Quibron T SR,Quibron TSR,Slo Phyllin,SloPhyllin,Sodium Glycinate, Theophylline,Somophyllin T,SomophyllinT,Theo 24,Theo Dur,Theo24,Theophyllinate, Glycine,Von Ct, Theo

Related Publications

A Tumba, and E Vamos-Hurwitz
Adenosine 3',5'-monophosphate and N 6 -2'-O-dibutyryl-adenosine 3',5'-monophosphate transport in cells.
September 1972, Science (New York, N.Y.),
A Tumba, and E Vamos-Hurwitz
Effect of N 6 O 2 -dibutyryl cyclic 3',5'-adenosine monophosphate on the pinocytosis of brain capillaries of mice.
December 1972, Experientia,
A Tumba, and E Vamos-Hurwitz
Uptake and metabolism of 3',5' -cyclic adenosine monophosphate and N 6 ,O 2' -dibutyryl 3',5' -cyclic adenosine monophosphate in isolated bovine thyroid cells.
April 1972, Biochimica et biophysica acta,
A Tumba, and E Vamos-Hurwitz
The effect of adenosine 3',5'-monophosphate and of N 6 -2'-O-dibutyryl-adenosine 3',5'-monophosphate on the mouse ovarian 5 -3 -hydroxysteroid dehydrogenase.
March 1971, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
A Tumba, and E Vamos-Hurwitz
Inhibition of lysosomal enzyme release by adenosine 5' triphosphate and N 6 ,O 2 -dibutyryl cyclic 3',5'-adenosine monophosphate.
April 1972, Life sciences. Pt. 1: Physiology and pharmacology,
A Tumba, and E Vamos-Hurwitz
The effect of cyclic N-2-O-dibutyryl-adenosine-3',5'-monophosphate, adenosine triphosphate and butyrate on the body temperature of conscious cats.
July 1973, Brain research,
A Tumba, and E Vamos-Hurwitz
Effect of N 6 , 2'-O-dibutyryl 3'5'-cyclic adenosine monophosphate, 3', 5',-cyclic adenosine monophosphate and adenosine triphosphate on acetylcholine output from cholinergic nerves in guinea pig ileum.
February 1972, Japanese journal of pharmacology,
A Tumba, and E Vamos-Hurwitz
Cyclic 3',5'-adenosine monophosphate in human blood platelets. II. Effect of N6-2'-o-dibutyryl cyclic 3',5'-adenosine monophosphate on platelet function.
January 1971, The Journal of clinical investigation,
A Tumba, and E Vamos-Hurwitz
Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate.
July 1975, Archives of biochemistry and biophysics,
A Tumba, and E Vamos-Hurwitz
N 6 ,O 2 '-dibutyryl adenosine 3',5'-monophosphate induces pigment production in melanoma cells.
June 1972, Nature: New biology,
Copied contents to your clipboard!