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Aldosterone antagonists. 4. Synthesis and activities of steroidal 6,6-ethylene-15,16-methylene 17-spirolactones. 1991
K Nickisch, and
S Beier, and
D Bittler, and
W Elger, and
H Laurent, and
W Losert, and
Y Nishino, and
E Schillinger, and
R Wiechert
Research Laboratories, Schering AG Berlin and Bergkamen, Berlin, Germany.
Several steroidal 6,6-ethylene-15,16-methylene 17-spirolactones were synthesized to find new progestogens that exhibit both progestational and antimineralocorticoidal activities. The influence of substituents in the 10- and 13-position of the steroidal framework on both properties was investigated. It was found that only compound 12, carrying methyl groups at the 10- and 13-positions, possesses high progestational and antimineralocorticoidal activity.
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