Biomaterial Database

Endothelin ETB receptor heterodimerization: beyond the ETA receptor. 2008

Erika I Boesen

1Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA.

The idea that endothelin ETA and ETB receptors may form homodimers and heterodimers has gained increasing interest in recent years. The existence of such interactions between endothelin receptors has the potential to explain some puzzling results from receptor binding and functional studies. Zeng and colleagues take ETB receptor heterodimerization beyond the ETA receptor, reporting renal endothelin ETB-dopamine D(3) receptor interactions at the cellular level that appear to have functional consequences in vivo.

UI	MeSH Term	Description	Entries
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D044022	Receptor, Endothelin A	A subtype of endothelin receptor found predominantly in the VASCULAR SMOOTH MUSCLE. It has a high affinity for ENDOTHELIN-1 and ENDOTHELIN-2.	Endothelin A Receptors,Endothelin Receptors Type A,Receptor, Endothelin-1,Endothelin A Receptor,Endothelin-1 Receptor,Receptor, Endothelin 1,Receptors, Endothelin A
D044023	Receptor, Endothelin B	A subtype of endothelin receptor found predominantly in the KIDNEY. It may play a role in reducing systemic ENDOTHELIN levels.	Endothelin B Receptors,Endothelin B-2 Receptor,Receptor, Endothelin B, Type 2,Endothelin B-2 Receptors,Endothelin B 2 Receptor,Endothelin B 2 Receptors,Endothelin B Receptor,Receptor, Endothelin B-2,Receptors, Endothelin B,Receptors, Endothelin B-2
D050637	Receptors, Dopamine D3	A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.	Dopamine D3 Receptors,Dopamine D3 Receptor,Dopamine Receptor D3,Receptor, Dopamine-D3,Dopamine-D3 Receptor
D019334	Endothelin-3	A 21-amino acid peptide that circulates in the plasma, but its source is not known. Endothelin-3 has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. It also is found throughout the gastrointestinal tract and in the lung and kidney. (N Eng J Med 1995;333(6):356-63)	Big Endothelin 3,Big Endothelin-3,Endothelin 3,Endothelin 3, Big,Endothelin-3, Big