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Calcium-channel antagonists inhibit marble-burying behavior in mice. 2008
Nobuaki Egashira, and
Ryoko Okuno, and
Moe Abe, and
Michihiko Matsushita, and
Kenichi Mishima, and
Katsunori Iwasaki, and
Ryozo Oishi, and
Ryoji Nishimura, and
Yoshiaki Matsumoto, and
Michihiro Fujiwara
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan. n-egashi@pharm.med.kyushu-u.ac.jp
In the present study, we examined the effects of calcium-channel antagonists on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Amlodipine (10 mg/kg, i.p.), cilnidipine (10 mg/kg, i.p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior.
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