Biomaterial Database

[Pathological changes of potential-activated calcium channels in sensory neurons]. 2008

O P Kostiuk, and V O Pinchenko, and P H Kostiuk

The review considers the structure and function of high-and low-voltage potential activated calcium channels in sensory neurons. A special attention is paid to compression of the function of these channels in normal conditions and during development of pathological conditions. The role of low-voltage activated T-type calcium channels during such forms of pathology as neuropathy, acidosis and alkalosis because the changes in synaptic transmission occurring during these forms of pathological changes are most intensively altered during changes in functional structures of these type of channels. During studying of high-voltage activated calcium channels main attention has been concentrated on changes in the function of N-type potential activated calcium channels.

UI	MeSH Term	Description	Entries
D009437	Neuralgia	Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	Nerve Pain,Neurodynia,Paroxysmal Nerve Pain,Neuralgia, Atypical,Neuralgia, Iliohypogastric Nerve,Neuralgia, Ilioinguinal,Neuralgia, Perineal,Neuralgia, Stump,Neuralgia, Supraorbital,Neuralgia, Vidian,Neuropathic Pain,Atypical Neuralgia,Atypical Neuralgias,Iliohypogastric Nerve Neuralgia,Iliohypogastric Nerve Neuralgias,Ilioinguinal Neuralgia,Ilioinguinal Neuralgias,Nerve Neuralgia, Iliohypogastric,Nerve Neuralgias, Iliohypogastric,Nerve Pain, Paroxysmal,Nerve Pains,Nerve Pains, Paroxysmal,Neuralgias,Neuralgias, Atypical,Neuralgias, Iliohypogastric Nerve,Neuralgias, Ilioinguinal,Neuralgias, Perineal,Neuralgias, Stump,Neuralgias, Supraorbital,Neuralgias, Vidian,Neurodynias,Neuropathic Pains,Pain, Nerve,Pain, Neuropathic,Pain, Paroxysmal Nerve,Pains, Nerve,Pains, Neuropathic,Pains, Paroxysmal Nerve,Paroxysmal Nerve Pains,Perineal Neuralgia,Perineal Neuralgias,Stump Neuralgia,Stump Neuralgias,Supraorbital Neuralgia,Supraorbital Neuralgias,Vidian Neuralgia,Vidian Neuralgias
D009475	Neurons, Afferent	Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.	Afferent Neurons,Afferent Neuron,Neuron, Afferent
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000138	Acidosis	A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.	Metabolic Acidosis,Acidoses,Acidoses, Metabolic,Acidosis, Metabolic,Metabolic Acidoses
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000471	Alkalosis	A pathological condition that removes acid or adds base to the body fluids.	Alkaloses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D020747	Calcium Channels, T-Type	A heterogenous group of transient or low voltage activated type CALCIUM CHANNELS. They are found in cardiac myocyte membranes, the sinoatrial node, Purkinje cells of the heart and the central nervous system.	Transient-Type Calcium Channels,Calcium Channel (T-Type),T-Type Calcium Channel,T-Type Calcium Channels,T-Type VDCC,T-Type Voltage-Dependent Calcium Channels,Calcium Channel, T-Type,Calcium Channels, T Type,Calcium Channels, Transient-Type,Channel, T-Type Calcium,Channels, T-Type Calcium,Channels, Transient-Type Calcium,T Type Calcium Channel,T Type Calcium Channels,T Type VDCC,T Type Voltage Dependent Calcium Channels,Transient Type Calcium Channels,VDCC, T-Type
D020864	Calcium Channels, N-Type	CALCIUM CHANNELS that are concentrated in neural tissue. Omega toxins inhibit the actions of these channels by altering their voltage dependence.	N-Type Calcium Channels,Neural-Type Calcium Channels,N-Type Calcium Channel,N-Type VDCC,N-Type Voltage-Dependent Calcium Channels,Calcium Channel, N-Type,Calcium Channels, N Type,Calcium Channels, Neural-Type,Channel, N-Type Calcium,Channels, N-Type Calcium,Channels, Neural-Type Calcium,N Type Calcium Channel,N Type Calcium Channels,N Type VDCC,N Type Voltage Dependent Calcium Channels,Neural Type Calcium Channels,VDCC, N-Type