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The first examples of mRNA cap analogs bearing boranophosphate modification. 2008

Joanna Kowalska, and Joanna Zuberek, and Zbigniew M Darzynkiewicz, and Maciej Lukaszewicz, and Edward Darzynkiewicz, and Jacek Jemielity
Division of Biophysics, Institute of Experimental Physics, University of Warsaw, 02-089 Warsaw, Poland.

The syntheses of mRNA cap analogs modified with boranophosphate moiety at either the alpha or beta-position of the 5', 5'-triphosphate bridge (m(7)Gppp(BH3)G, m(7)Gpp(BH3)pG and m(7)Gpp(BH3)pm(7)G) are described. The preliminary biological characterization of these compounds revealed that they have high affinity for translational factor eIF4E and high potency to inhibit cap-dependent translation in cell free system. The analogs modified at the beta-position were also found to be resistant to DcpS decapping pyrophosphatase.

UI MeSH Term Description Entries
D010710 Phosphates Inorganic salts of phosphoric acid. Inorganic Phosphate,Phosphates, Inorganic,Inorganic Phosphates,Orthophosphate,Phosphate,Phosphate, Inorganic
D001880 Boranes The collective name for the boron hydrides, which are analogous to the alkanes and silanes. Numerous boranes are known. Some have high calorific values and are used in high-energy fuels. (From Grant & Hackh's Chemical Dictionary, 5th ed) Borane,Boron Hydride,Boron Hydrides,Hydride, Boron,Hydrides, Boron
D012314 RNA Cap Analogs Analogs of RNA cap compounds which do not have a positive charge. These compounds inhibit the initiation of translation of both capped and uncapped messenger RNA. RNA Cap Analogues,Analogs, RNA Cap,Analogues, RNA Cap,Cap Analogs, RNA,Cap Analogues, RNA
D014176 Protein Biosynthesis The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS. Genetic Translation,Peptide Biosynthesis, Ribosomal,Protein Translation,Translation, Genetic,Protein Biosynthesis, Ribosomal,Protein Synthesis, Ribosomal,Ribosomal Peptide Biosynthesis,mRNA Translation,Biosynthesis, Protein,Biosynthesis, Ribosomal Peptide,Biosynthesis, Ribosomal Protein,Genetic Translations,Ribosomal Protein Biosynthesis,Ribosomal Protein Synthesis,Synthesis, Ribosomal Protein,Translation, Protein,Translation, mRNA,mRNA Translations
D039561 Eukaryotic Initiation Factor-4E A peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F. EIF-4E,Peptide Initiation Factor EIF-4E,CDC33 Gene Product,EIF4E,Eukaryotic Peptide Initiation Factor-4E,EIF 4E,Eukaryotic Initiation Factor 4E,Eukaryotic Peptide Initiation Factor 4E,Factor-4E, Eukaryotic Initiation,Initiation Factor-4E, Eukaryotic,Peptide Initiation Factor EIF 4E

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