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Nuclear DNA content of 27 phaeochromocytomas was measured by image analysis of thin sections and monolayer smears of nuclei extracted from thick sections (cytospins) using archival paraffin-embedded tissue blocks. Recurrence was assessed on the basis of clinical follow-up or urinary catecholamine levels. The mean follow-up was 5.0 years, with a range of 4 months to 15 years. Although it is not possible to differentiate accurately malignant tumours using DNA analysis, prediction of benign tumours is possible. Using thin sections, all tumours were benign when the percentage of cells with a DNA content of 2.5 c (2 c = diploid) was less than 40% and the DNA content of 5 c was less than 4%. Using the cytospin preparation, all diploid tumours were benign. Thus, patients with diploid tumours may be saved intensive long-term follow-up. Aneuploid and tetraploid tumours, however, continue to require careful lifelong follow-up.
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
February 2000,
Annals of diagnostic pathology,
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
December 1980,
Analytical and quantitative cytology,
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
March 1990,
Nihon Gan Chiryo Gakkai shi,
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
November 1993,
Zhonghua wai ke za zhi [Chinese journal of surgery],
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
March 1992,
Cancer,
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
May 1984,
Cancer research,
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
July 1991,
International journal of cancer,
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
January 1984,
Cancer research,
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
October 1990,
Analytical and quantitative cytology and histology,
C Cope, and
L Delbridge, and
J Philips, and
M Friedlander
April 1990,
Wiener klinische Wochenschrift,
