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Recent reports of reduced seizure duration with ECT under propofol anaesthesia have led to concerns that propofol may diminish the efficacy of this treatment. To investigate the effect of propofol on the response to ECT, we reviewed records of 66 patients with primary depression treated with ECT, 37 of whom had been assessed prospectively with pre- and post-ECT Hamilton and Zung depression severity ratings. Despite demonstrating that the individual seizure duration was significantly reduced with propofol compared to thiopentone we found no evidence of reduced ECT efficacy with propofol. Courses under propofol anaesthesia were on an average two treatments longer than with thiopentone. Although this difference was not statistically significant this may have been due to a type II error. These results suggest that it is premature to abandon the use of this new anaesthetic agent in ECT without controlled prospective outcome studies.
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
April 1987,
The Veterinary record,
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
January 1973,
The British journal of psychiatry : the journal of mental science,
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
January 1991,
British journal of anaesthesia,
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
May 1991,
Acta anaesthesiologica Scandinavica,
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
January 1989,
The Veterinary record,
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
December 1987,
British journal of anaesthesia,
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
June 1995,
The Australian and New Zealand journal of psychiatry,
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
July 1990,
Acta anaesthesiologica Scandinavica,
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
January 2010,
Bratislavske lekarske listy,
P Mitchell, and
T Torda, and
I Hickie, and
C Burke
February 1991,
Anaesthesia and intensive care,
