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Bleeding time is prolonged following resection of kidney tissue as well as after ureteral occlusion. Bilateral nephrectomy raises bleeding time from 17 to 67 min, and blood loss can be increased from 2 to 12 microliters/min. Plasmatic coagulation factors remain unchanged in uremic rats. There is no influence of various surgical interventions producing uremia on function of thrombocytes. In rats with intact kidney function and following bilateral nephrectomy a diminution of bleeding time is demonstrable after administration of histamine or captopril. Shortening of bleeding time by the antifibrinolytic substance p-aminomethylbenzoic acid seems to indicate an increased fibrinolytic activity in uremic rats.
H Sprott, and
C Fleck, and
H Bräunlich
January 1988,
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H Sprott, and
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H Bräunlich
January 1969,
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H Sprott, and
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November 1989,
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H Sprott, and
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H Bräunlich
April 1994,
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H Sprott, and
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H Sprott, and
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H Sprott, and
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H Sprott, and
C Fleck, and
H Bräunlich
August 1986,
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H Sprott, and
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H Sprott, and
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