-transparent.png){kind=logo}
The allotypes of C6, C7, factor B (BF) and factor I (IF) of the human complement system were studied in 11 Japanese patients with pemphigus (5 with pemphigus vulgaris and 6 with pemphigus foliaceus) and 17 with bullous pemphigoid (BP) to investigate the genetic background of these diseases. The allotypes were detected by using isoelectric focusing and immunoblotting. The frequency for IF*A allele in the pemphigus patients was significantly higher (p = 0.009) than that in healthy controls (n = 60). A significant association of IF A allotype with pemphigus was also observed (p = 0.027), with a relative risk of 6.3. There was no association between the C6, C7, BF or IF allotypes and BP. These data suggest that IF A allotype may be an etiological genetic factor in the development of pemphigus.
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
September 1976,
The Journal of investigative dermatology,
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
January 1989,
Dermatologica,
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
May 1979,
International journal of dermatology,
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
August 1999,
Lancet (London, England),
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
January 1980,
IMJ. Illinois medical journal,
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
March 2008,
Acta clinica Croatica,
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
June 2017,
BMJ (Clinical research ed.),
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
March 1983,
Annals of allergy,
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
January 1994,
Dermatology (Basel, Switzerland),
H Nishimukai, and
S Shiraishi, and
Y Shirakata, and
K Sayama, and
T Shinomiya, and
Y Miki
January 1989,
Vestnik dermatologii i venerologii,
