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The mechanisms of blood coagulation and fibrinolysis have been evaluated in 28 black adult Africans with primary hepato-cellular carcinoma (HCC). A characteristic pattern of abnormalities has been defined. Dysfibrinogenaemia appears to be a useful biological marker for the disease. The reptilase test (RT) is a simple, reliable and sensitive means of detection of this metabolic abnormality. It is suggested that the RT should be used to screen populations at high risk of developing HCC, such as cirrhotics, in conjunction with alpha fetoprotein determinations, which, alone, are inadequate for the purpose. The haemostatic defect may have relevance to the pathogenesis of HCC, and further suggests a potentially useful, additional, therapeutic modality.
R D Barr, and
N Ouna, and
J G Simpson, and
A F Bagshawe
June 1992,
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R D Barr, and
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A F Bagshawe
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R D Barr, and
N Ouna, and
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A F Bagshawe
August 1983,
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R D Barr, and
N Ouna, and
J G Simpson, and
A F Bagshawe
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R D Barr, and
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A F Bagshawe
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R D Barr, and
N Ouna, and
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A F Bagshawe
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R D Barr, and
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J G Simpson, and
A F Bagshawe
January 2024,
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences,
R D Barr, and
N Ouna, and
J G Simpson, and
A F Bagshawe
May 2011,
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology,
R D Barr, and
N Ouna, and
J G Simpson, and
A F Bagshawe
January 2005,
Revue medicale suisse,
