Neuropsychological effects of shunt treatment in idiopathic normal pressure hydrocephalus. 2008

Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
Institute of Neuroscience and Physiology, Göteborg University, Gothenburg, Sweden. per.hellstrom@vgregion.se

OBJECTIVE To prospectively evaluate the effects of shunting on the neuropsychological performance of patients with idiopathic normal pressure hydrocephalus (INPH), to compare their performance with that of healthy individuals, and to estimate the predictive utility of putatively important factors. METHODS A consecutive series of 47 patients with INPH underwent neurological, radiological, and neuropsychological examinations before and 3 months after shunt surgery. The same neuropsychological tests, measuring simple and target reaction times, dexterity, memory and learning, working memory, and aspects of executive functioning, were also administered to 159 healthy individuals. RESULTS Performance on all neuropsychological tests, except Simple Reaction Time and Digit Span, significantly improved after surgery, with more severe functional deficits showing greatest improvement. Age, education, duration, vascular comorbidity, sex, and onset symptom all failed to predict the neuropsychological effects of treatment. Despite improvement 3 months after shunt surgery, INPH patients were still outperformed by healthy individuals. CONCLUSIONS Most of the wide range of neuropsychological functions that are affected by INPH are markedly improved by shunt treatment, but not completely restored.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009483 Neuropsychological Tests Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury. Aphasia Tests,Cognitive Test,Cognitive Testing,Cognitive Tests,Memory for Designs Test,Neuropsychological Testing,AX-CPT,Behavioral Assessment of Dysexecutive Syndrome,CANTAB,Cambridge Neuropsychological Test Automated Battery,Clock Test,Cognitive Function Scanner,Continuous Performance Task,Controlled Oral Word Association Test,Delis-Kaplan Executive Function System,Developmental Neuropsychological Assessment,Hooper Visual Organization Test,NEPSY,Neuropsychologic Tests,Neuropsychological Test,Paced Auditory Serial Addition Test,Repeatable Battery for the Assessment of Neuropsychological Status,Rey-Osterrieth Complex Figure,Symbol Digit Modalities Test,Test of Everyday Attention,Test, Neuropsychological,Tests, Neuropsychological,Tower of London Test,Neuropsychologic Test,Test, Cognitive,Testing, Cognitive,Testing, Neuropsychological,Tests, Cognitive
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D011597 Psychomotor Performance The coordination of a sensory or ideational (cognitive) process and a motor activity. Perceptual Motor Performance,Sensory Motor Performance,Visual Motor Coordination,Coordination, Visual Motor,Coordinations, Visual Motor,Motor Coordination, Visual,Motor Coordinations, Visual,Motor Performance, Perceptual,Motor Performance, Sensory,Motor Performances, Perceptual,Motor Performances, Sensory,Perceptual Motor Performances,Performance, Perceptual Motor,Performance, Psychomotor,Performance, Sensory Motor,Performances, Perceptual Motor,Performances, Psychomotor,Performances, Sensory Motor,Psychomotor Performances,Sensory Motor Performances,Visual Motor Coordinations
D002557 Cerebrospinal Fluid Shunts Tubes inserted to create communication between a cerebral ventricle and the internal jugular vein. Their emplacement permits draining of cerebrospinal fluid for relief of hydrocephalus or other condition leading to fluid accumulation in the ventricles. Cerebrospinal Fluid Shunt,Shunt, Cerebrospinal Fluid,Shunts, Cerebrospinal Fluid
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006850 Hydrocephalus, Normal Pressure A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see GAIT DISORDERS, NEUROLOGIC), progressive intellectual decline, and URINARY INCONTINENCE. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of CSF including SUBARACHNOID HEMORRHAGE, chronic MENINGITIS, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3) Hakim Syndrome,Normal Pressure Hydrocephalus,Hakim's Syndrome,Hydrocephalus, Normal-Pressure,NPH (Normal Pressure Hydrocephalus),Hakim Syndromes,Hakim's Syndromes,Hakims Syndrome,NPHs (Normal Pressure Hydrocephalus),Syndrome, Hakim,Syndrome, Hakim's,Syndromes, Hakim,Syndromes, Hakim's
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
January 2022, Tzu chi medical journal,
Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
September 2004, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology,
Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
February 2019, Journal of neurosurgery,
Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
November 2022, Neuroradiology,
Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
January 2021, American journal of translational research,
Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
January 2013, Neurosurgery,
Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
April 2021, European journal of neurology,
Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
June 2017, Clinical neurology and neurosurgery,
Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
March 2008, Brain and nerve = Shinkei kenkyu no shinpo,
Per Hellström, and Mikael Edsbagge, and Elisabeth Blomsterwall, and Trevor Archer, and Magnus Tisell, and Mats Tullberg, and Carsten Wikkelsø
January 2021, Frontiers in surgery,
Copied contents to your clipboard!