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The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with a different C-terminus, which is not packaged in granules. In addition, the expression of a coexisting peptide, angiotensin II (Ang II), is disturbed. During postnatal life a small but increasing number of solitary post-mitotic hypothalamic neurons of the di/di rat undergoes a switch to a genuine heterozygous phenotype. Here we report the reappearance of Ang II in these heterozygous cells, which suggests that for the expression of Ang II a normal VP precursor is required. Based upon the present study and literature data it is proposed that at the level of the endoplasmic reticulum a compartmentalization of the synthesis of various peptide precursor occurs.
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
July 1992,
Brain research,
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
November 1985,
Neuroscience,
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
January 1986,
Neuroendocrinology,
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
July 1990,
The Journal of clinical investigation,
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
January 1982,
Annals of the New York Academy of Sciences,
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
November 1986,
The American journal of physiology,
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
December 1997,
Neuroscience letters,
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
January 1982,
Annals of the New York Academy of Sciences,
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
January 1994,
Brain research,
F W van Leeuwen, and
E M vd Beek, and
J J van Heerikhuize, and
A A Sluiter, and
D Felix, and
H Imboden
January 2006,
Neuroscience letters,
