Adaptive and nonadaptive responses to voluntary wheel running by mdx mice. 2008

Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
Program in Physical Therapy, University of Minnesota School of Medicine, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA.

The purpose of this study was to determine the extent to which hindlimb muscles of mdx mice adapt to a voluntary endurance type of exercise. mdx and C57BL mice engaged in 8 weeks of wheel running or maintained normal cage activities. Beneficial adaptations that occurred in mdx mice included changes in muscle mass, fiber size, and fiber types based on myosin heavy chain (MHC) isoform expression. These adaptations occurred without increases in fiber central nuclei and embryonic MHC expression. An undesirable outcome, however, was that muscle mitochondrial enzyme activities did not improve with exercise in mdx mice as they did in C57BL mice. Cellular remodeling of dystrophic muscle following exercise has not been studied adequately. In this study we found that some, but not all, of the expected adaptations occurred in mdx mouse muscle. We must better understand these (non)adaptations in order to inform individuals with DMD about the benefits of exercise.

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008928 Mitochondria Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed) Mitochondrial Contraction,Mitochondrion,Contraction, Mitochondrial,Contractions, Mitochondrial,Mitochondrial Contractions
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D009137 Muscular Dystrophy, Animal MUSCULAR DYSTROPHY that occurs in VERTEBRATE animals. Animal Muscular Dystrophies,Animal Muscular Dystrophy,Dystrophies, Animal Muscular,Dystrophy, Animal Muscular,Muscular Dystrophies, Animal
D010805 Physical Conditioning, Animal Diet modification and physical exercise to improve the ability of animals to perform physical activities. Animal Physical Conditioning,Animal Physical Conditionings,Conditioning, Animal Physical,Conditionings, Animal Physical,Physical Conditionings, Animal
D012038 Regeneration The physiological renewal, repair, or replacement of tissue. Endogenous Regeneration,Regeneration, Endogenous,Regenerations
D002467 Cell Nucleus Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) Cell Nuclei,Nuclei, Cell,Nucleus, Cell
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005260 Female Females

Related Publications

Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
June 2021, Molecular therapy. Methods & clinical development,
Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
December 2010, Muscle & nerve,
Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
December 2015, Current protocols in mouse biology,
Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
December 2021, Molecular therapy. Methods & clinical development,
Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
September 2008, Journal of applied physiology (Bethesda, Md. : 1985),
Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
July 1995, Neuromuscular disorders : NMD,
Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
June 2010, International journal of obesity (2005),
Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
December 2018, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
December 2011, PLoS currents,
Rachel M Landisch, and Allison M Kosir, and Steven A Nelson, and Kristen A Baltgalvis, and Dawn A Lowe
January 2023, Frontiers in physiology,
Copied contents to your clipboard!