BIOMAT Database Logo BIOMAT Database Logo

Retinoblastoma in Great Britain 1963-2002. 2009

A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Childhood Cancer Research Group, University of Oxford, 57 Woodstock Road, Oxford OX2 6HJ, UK. angela.maccarthy@ccrg.ox.ac.uk

OBJECTIVE This paper describes the epidemiology and family history status of 1601 children with retinoblastoma in Great Britain diagnosed 1963-2002 and summarises the practical consequences for diagnosis and counselling of developments in molecular genetics. METHODS Incidence rates were analysed according to year of diagnosis and tumour laterality. Cases were classified as heritable or non-heritable on the basis of laterality and family history of the disease. RESULTS There were 998 unilateral cases, 581 bilateral and 22 of unknown laterality. Bilateral cases tended to be diagnosed at a younger age than unilateral. All bilateral cases are regarded as heritable, and 35% had a family history of the disease. 7% of the unilateral cases had a family history and are therefore heritable. Thus, at least (41%) of our cases are heritable. This is an underestimate, since these data on family history are incomplete. For unilateral cases aged below 1 year, the reported incidence rate increased significantly (p<0.0001) by about 2.5% per year; for the age group 1-4 years, the average increase was about 0.5% per year (not significant).

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297 Male Males
D012042 Registries The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers. Parish Registers,Population Register,Parish Register,Population Registers,Register, Parish,Register, Population,Registers, Parish,Registers, Population,Registry
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D005817 Genetic Counseling An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered. Counseling, Genetic,Genetic Counseling, Prenatal,Prenatal Genetic Counseling
D006113 United Kingdom Country in northwestern Europe including Great Britain and the northern one-sixth of the island of Ireland, located between the North Sea and north Atlantic Ocean. The capital is London. Great Britain,Isle of Man
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Angiosarcoma of the liver in Great Britain, 1963-73.
October 1977, British medical journal,
A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
MEASUREMENT OF SERUM URIC ACID IN GREAT BRITAIN IN 1963.
May 1964, Annals of the rheumatic diseases,
A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Scientific procedures on living animals in Great Britain 2002.
November 2003, Alternatives to laboratory animals : ATLA,
A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Retinoblastoma in Great Britain 1969-80: incidence, treatment, and survival.
August 1988, The British journal of ophthalmology,
A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Proceedings of the Anatomical Society of Great Britain and Ireland, April 1963 and July 1963.
October 1963, Journal of anatomy,
A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Medical wastage of military and civil aircrew in Great Britain 1963-68.
May 1970, Aerospace medicine,
A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Non-ocular tumours following retinoblastoma in Great Britain 1951 to 2004.
September 2009, The British journal of ophthalmology,
A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Primary drug resistance in pulmonary tuberculosis in Great Britain: second national survey, 1963.
March 1966, Tubercle,
A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Characterisation of influenza viruses isolated from turkeys in Great Britain during 1963--1977.
January 1979, Research in veterinary science,
A MacCarthy, and J M Birch, and G J Draper, and J L Hungerford, and J E Kingston, and M E Kroll, and Z Onadim, and C A Stiller, and T J Vincent, and M F G Murphy
Rhinoviruses in Britain 1963-1973.
February 1976, The Journal of hygiene,
Copied contents to your clipboard!