BIOMAT Database Logo BIOMAT Database Logo

Insulin sensitivity in zinc-depleted rats: assessment with the euglycaemic hyperinsulinic clamp technique. 1991

P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
Laboratoire de Biochimie Pharmaceutique, Université Joseph-Fourier, UFR de Pharmacie, Domaine de la Merci, La Tronche, France.

The present knowledge about zinc deficiency and insulin-sensitivity is not yet established. Using three groups of rats fed zinc-depleted diet (ZD) zinc adequate diets, either Pair Fed or ad libitum for a six weeks period, we measured the glucose turn over by the euglycaemic hyperinsulinaemic clamp technique coupled with tritiated glucose as tracer. The basal hepatic glucose production (HGP) and insulinaemia were lower in zinc-depleted rats. At a low rate of insulin infusion (0.6 mU/min/rat) the zinc-depleted rats did not show any difference in hepatic insulin sensitivity compared with the pair-fed animals. At high level of insulin rate (3 mU/min/rat; 9 mU/min/rat), the zinc-depleted rats exhibited a lower glucose uptake compared to the two control groups (Pair-fed and Ad libitum animals). This peripheral insulin resistance is therefore related to a modification of insulin receptors, or post receptors events in zinc deficiency.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007332 Insulin Infusion Systems Portable or implantable devices for infusion of insulin. Includes open-loop systems which may be patient-operated or controlled by a pre-set program and are designed for constant delivery of small quantities of insulin, increased during food ingestion, and closed-loop systems which deliver quantities of insulin automatically based on an electronic glucose sensor. Pancreas, Artificial Endocrine,Programmable Implantable Insulin Pump,beta Cell, Artificial,Implantable Programmable Insulin Pump,Insulin Pump, Programmable Implantable,Pump, Programmable Implantable Insulin,Artificial Endocrine Pancreas,Artificial beta Cell,Artificial beta Cells,Cell, Artificial beta,Cells, Artificial beta,Endocrine Pancreas, Artificial,Infusion System, Insulin,Infusion Systems, Insulin,Insulin Infusion System,System, Insulin Infusion,Systems, Insulin Infusion,beta Cells, Artificial
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D009206 Myocardium The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D001842 Bone and Bones A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX. Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone

Related Publications

P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
[Insulin sensitivity measured with euglycaemic clamp technique in newly diagnosed diabetes mellitus].
August 2001, Polskie Archiwum Medycyny Wewnetrznej,
P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
Application of the euglycaemic clamp technique to bioassay of insulin analogues.
June 1992, Biologicals : journal of the International Association of Biological Standardization,
P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
The short insulin tolerance test for determination of insulin sensitivity: a comparison with the euglycaemic clamp.
June 1992, Diabetic medicine : a journal of the British Diabetic Association,
P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
Heritability and genetic correlations of insulin sensitivity measured by the euglycaemic clamp.
November 2007, Diabetic medicine : a journal of the British Diabetic Association,
P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic-euglycaemic clamp.
January 2018, Diabetes, obesity & metabolism,
P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
Insulin sensitivity assessed by stable isotopes with oral glucose administration: validation with euglycaemic clamp.
January 2013, ISRN endocrinology,
P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
Surrogate measures of insulin sensitivity vs the hyperinsulinaemic-euglycaemic clamp: a meta-analysis.
September 2014, Diabetologia,
P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
Assessment of insulin sensitivity in older adults using the hyperglycemic clamp technique.
January 1998, Journal of the American Geriatrics Society,
P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
Pharmacokinetic and glucodynamic variability: assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp technique.
October 2005, Diabetologia,
P Faure, and A M Roussel, and M Martinie, and M Osman, and A Favier, and S Halimi
Physiological changes in insulin resistance in human pregnancy: longitudinal study with the hyperinsulinaemic euglycaemic clamp technique.
July 1998, British journal of obstetrics and gynaecology,
Copied contents to your clipboard!