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The interaction of human chorionic gonadotropin (hCG) with rat adipose tissue was investigated by both metabolic and binding studies. Highly purified preparations of hCG did not affect the adenylate cyclase activity nor the lipolysis of rat adipocytes in the presence or in the absence of GTP. However, it was demonstrated that (a) the hCGs used were biologically active since they stimulated cAMP and testosterone production by rat Leydig cells, and (b) there are receptor sites on the rat ovary that bind [125I]hCG and recognize rat luteinizing hormone (LH). The lack of response cannot then be attributed to a loss of activity of the hormone preparation tested nor to a failure of the rat tissues to recognize an hormone of human origin, but rather to an absence of hCG--LH receptors on the fat cell membrane surface. It is suggested that results previously reported in other laboratories could be explained by the presence of contaminating amounts of lipolytic hormones in their preparations.
G P Tell, and
F Haour, and
J M Saez
June 1978,
Molecular and cellular endocrinology,
G P Tell, and
F Haour, and
J M Saez
July 1977,
Molecular and cellular endocrinology,
G P Tell, and
F Haour, and
J M Saez
July 1983,
Experimental and clinical endocrinology,
G P Tell, and
F Haour, and
J M Saez
March 1981,
Archives of andrology,
G P Tell, and
F Haour, and
J M Saez
January 1999,
Biochimica et biophysica acta,
G P Tell, and
F Haour, and
J M Saez
January 1986,
Molecular and cellular endocrinology,
G P Tell, and
F Haour, and
J M Saez
June 1994,
FEBS letters,
G P Tell, and
F Haour, and
J M Saez
January 1973,
Advances in experimental medicine and biology,
G P Tell, and
F Haour, and
J M Saez
January 1981,
Differentiation; research in biological diversity,
G P Tell, and
F Haour, and
J M Saez
October 1988,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
