Biomaterial Database

Prevention by medroxyprogesterone of perforation in the alkali-burned rabbit cornea: inhibition of collagenolytic activity. 1977

N A Newsome, and J Gross

The incidence of perforation and deep ulceration of the alkali-burned rabbit cornea was substantially reduced by topical or parenteral administration of medroxyprogesterone. The mode of action of the hormone is probably at least in part related to its suppressive effects on production of tissue collagenase, as indicated by the considerable reduction in collagenolytic activity by living explants of the treated corneas.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008525	Medroxyprogesterone	A synthetic progestational hormone used in veterinary practice as an estrus regulator.	(6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione,Methylhydroxyprogesterone,Pregn-4-ene-3,20-dione, 17-hydroxy-6-methyl-, (6alpha)-,17 alpha-Hydroxy-6 alpha-Methylprogesterone,Adgyn Medro,17 alpha Hydroxy 6 alpha Methylprogesterone
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002057	Burns, Chemical	Burns caused by contact with or exposure to CAUSTICS or strong ACIDS.	Chemical Burns,Burn, Chemical,Chemical Burn
D003012	Microbial Collagenase	A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.	Clostridiopeptidase A,Clostridium histolyticum Collagenase,Collagenase, Microbial,Collagenase Clostridium histolyticum,Collagenase-Like Peptidase,Collalysine,Nucleolysin,Clostridium histolyticum, Collagenase,Collagenase Like Peptidase,Collagenase, Clostridium histolyticum,Peptidase, Collagenase-Like,histolyticum, Collagenase Clostridium
D003094	Collagen	A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).	Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D003316	Corneal Diseases	Diseases of the cornea.	Corneal Disease,Disease, Corneal,Diseases, Corneal
D004334	Drug Administration Schedule	Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.	Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004343	Drug Implants	Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.	Drug Implant,Drug Pellet,Pellets, Drug,Drug Pellets,Implant, Drug,Implants, Drug,Pellet, Drug
D005126	Eye Burns	Injury to any part of the eye by extreme heat, chemical agents, or ultraviolet radiation.	Burn, Eye,Burns, Eye,Eye Burn

Related Publications

N A Newsome, and J Gross

Collagenolytic activity of alkali-burned corneas.

March 1969, Archives of ophthalmology (Chicago, Ill. : 1960),

N A Newsome, and J Gross

Histochemical study of leukocyte elastase activity in alkali-burned rabbit cornea.

January 1997, Ophthalmic research,

N A Newsome, and J Gross

Enzymatic activity of beta-N-acetylglucosaminidase in the alkali-burned rabbit cornea.

January 1982, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,

N A Newsome, and J Gross

Collagenase activity in the alkali-burned cornea.

June 1971, Annals of ophthalmology,

N A Newsome, and J Gross

Endothelial F-actin changes in the alkali burned rabbit cornea.

December 1994, Yonsei medical journal,

N A Newsome, and J Gross

Short-term re-epithelialization of the alkali-burned rabbit cornea.

November 1985, Annals of ophthalmology,

N A Newsome, and J Gross

Catecholaminergic nerve fibres in normal and alkali-burned rabbit cornea.

August 1998, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,