BIOMAT Database Logo BIOMAT Database Logo

Measurement of tissue lithium concentration by lithium magnetic resonance spectroscopy in patients with bipolar disorder. 1991

L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
Department of Psychiatry, University of Pennsylvania, Philadelphia.

Measurements of the lithium concentration in the occipital pole of the head and calf muscle of nine patients with bipolar disorder in remission were performed using in vivo lithium-7 nuclear magnetic resonance spectroscopy (7Li NMR). 7Li NMR measurements were performed on a 1-m-bore, 1.85-T, superconducting magnet supplemented with a multinuclear spectrometer, using 11.5-cm-diameter surface coils. The average lithium concentration in the occipital pole was 0.36 +/- 0.10 mEq/L, whereas in the muscle it was 0.50 +/- 0.17 mEq/L, both lower than the average serum lithium concentration (0.79 +/- 0.23 mEq/L). The average brain/serum lithium concentration ratio was 0.47 +/- 0.12 whereas the average muscle/serum lithium concentration ratio was 0.66 +/- 0.20. There was a positive correlation between the brain versus serum and brain versus muscle lithium concentrations. The hypothesis is advanced that the minimal effective concentration of brain lithium concentration for maintenance treatment of bipolar disorder is around 0.2-0.3 mEq/L.

UI MeSH Term Description Entries
D008094 Lithium An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER. Lithium-7,Lithium 7
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009132 Muscles Contractile tissue that produces movement in animals. Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D009778 Occipital Lobe Posterior portion of the CEREBRAL HEMISPHERES responsible for processing visual sensory information. It is located posterior to the parieto-occipital sulcus and extends to the preoccipital notch. Annectant Gyrus,Calcarine Fissure,Calcarine Sulcus,Cuneate Lobule,Cuneus,Cuneus Cortex,Cuneus Gyrus,Gyrus Lingualis,Lingual Gyrus,Lunate Sulcus,Medial Occipitotemporal Gyrus,Occipital Cortex,Occipital Gyrus,Occipital Region,Occipital Sulcus,Sulcus Calcarinus,Calcarine Fissures,Calcarinus, Sulcus,Cortex, Cuneus,Cortex, Occipital,Cortices, Cuneus,Cortices, Occipital,Cuneate Lobules,Cuneus Cortices,Fissure, Calcarine,Fissures, Calcarine,Gyrus Linguali,Gyrus, Annectant,Gyrus, Cuneus,Gyrus, Lingual,Gyrus, Medial Occipitotemporal,Gyrus, Occipital,Linguali, Gyrus,Lingualis, Gyrus,Lobe, Occipital,Lobes, Occipital,Lobule, Cuneate,Lobules, Cuneate,Occipital Cortices,Occipital Lobes,Occipital Regions,Occipitotemporal Gyrus, Medial,Region, Occipital,Regions, Occipital,Sulcus, Calcarine,Sulcus, Lunate,Sulcus, Occipital
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001714 Bipolar Disorder A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence. Affective Psychosis, Bipolar,Bipolar Disorder Type 1,Bipolar Disorder Type 2,Bipolar Mood Disorder,Depression, Bipolar,Manic Depression,Manic Disorder,Manic-Depressive Psychosis,Psychosis, Manic-Depressive,Type 1 Bipolar Disorder,Type 2 Bipolar Disorder,Psychoses, Manic-Depressive,Bipolar Affective Psychosis,Bipolar Depression,Bipolar Disorders,Bipolar Mood Disorders,Depression, Manic,Depressions, Manic,Disorder, Bipolar,Disorder, Bipolar Mood,Disorder, Manic,Manic Depressive Psychosis,Manic Disorders,Mood Disorder, Bipolar,Psychoses, Bipolar Affective,Psychoses, Manic Depressive,Psychosis, Bipolar Affective,Psychosis, Manic Depressive

Related Publications

L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
Brain lithium concentration by 7Li- and 1H-magnetic resonance spectroscopy in bipolar disorder.
May 1992, Psychiatry research,
L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder.
September 2013, Psychiatry research,
L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
Duration of lithium treatment and brain lithium concentration in patients with unipolar and schizoaffective disorder--a study with magnetic resonance spectroscopy.
April 1997, Biological psychiatry,
L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
[Magnetic resonance spectroscopy (MRS) applications in bipolar disorder].
January 2004, Turk psikiyatri dergisi = Turkish journal of psychiatry,
L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
In vivo measurement of lithium in humans by nuclear magnetic resonance spectroscopy.
March 1988, Biological psychiatry,
L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
Lithium side effects in relation to brain lithium concentration measured by lithium-7 magnetic resonance spectroscopy.
January 1996, Progress in neuro-psychopharmacology & biological psychiatry,
L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis.
August 2012, Bipolar disorders,
L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
Tissue pH measurement by magnetic resonance spectroscopy and imaging.
January 2006, Methods in molecular medicine,
L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
Measurement of human brain dexfenfluramine concentration by 19F magnetic resonance spectroscopy.
July 1999, Brain research,
L Gyulai, and S W Wicklund, and R Greenstein, and M S Bauer, and P Ciccione, and P C Whybrow, and J Zimmerman, and G Kovachich, and W Alves
Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder.
May 1999, Psychological medicine,
Copied contents to your clipboard!