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15-Deoxyspergualin (DSG), an immunosuppressive agent used in organ transplantation, exerts metabolic and antiproliferative effects on methicillin- and gentamicin-resistant Staphylococcus aureus and other bacteria (e.g. Sarcina lutea, Bacillus subtilis, Shigella sonnei, Salmonella typhi and Citrobacter freundii). DSG, at the concentration of 20 mg/l, depleted intracellular putrescine and spermidine in S. aureus to 43 and 40% of the controls, respectively. In these polyamine-depleted S. aureus cells, the synthesis of protein, DNA and RNA was decreased to 20, 85, 78% of the controls. The minimal inhibitory concentrations (MIC) of DSG for growth of S. aureus, S. lutea, B. subtilis, S. sonnei, S. typhi and C. freundii were 17, 13, 7, 15, 4, and 29 mg/l, respectively.
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
April 2010,
International journal of nanomedicine,
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
August 2000,
Journal of medical microbiology,
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
January 1962,
Rassegna medica sarda,
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
February 2018,
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences,
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
February 1988,
Transplantation proceedings,
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
February 2012,
International journal of food microbiology,
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
June 2010,
The Journal of toxicological sciences,
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
May 2016,
The Journal of antimicrobial chemotherapy,
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
March 2001,
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
H Hibasami, and
Y Midorikawa, and
P Gasaluck, and
H Yoshimura, and
A Masuji, and
S Takaji, and
K Nakashima, and
M Imai
July 1989,
The Journal of antimicrobial chemotherapy,
