Biomaterial Database

[Auditory event-related potentials in Parkinson's disease]. 1991

Z Y Zhoa

People Hospital, Beijing Medical University.

The results of event-related potential (ERP) components were studied in 25 cases of Parkinson's disease. This study included 33 normal volunteers (14 females and 19 males). With no prior history of neurologic or psychiatric illness. They were all over 50 years of age in "Auditory oddball" event-related potential paradigm. All of the Patients (20 males and 5 females) were 45-80 year's old. The latencies of the patients on N2P3aP3b wave which reflected cognitive process (activity) were significantly prolonged (P less than 0.001, P less than 0.001, P less than 0.02). The amplitude of P3a, P3b wave were decreased (P less than 0.001). This cognitive function were markedly different from normal. It's valuable in the diagnosis and follow up of Parkinson's disease. The origin of waves of ERP components and clinical application were also discussed in this paper.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010300	Parkinson Disease	A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)	Idiopathic Parkinson Disease,Lewy Body Parkinson Disease,Paralysis Agitans,Primary Parkinsonism,Idiopathic Parkinson's Disease,Lewy Body Parkinson's Disease,Parkinson Disease, Idiopathic,Parkinson's Disease,Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinsonism, Primary
D003071	Cognition	Intellectual or mental process whereby an organism obtains knowledge.	Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive
D005072	Evoked Potentials, Auditory	The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.	Auditory Evoked Potentials,Auditory Evoked Response,Auditory Evoked Potential,Auditory Evoked Responses,Evoked Potential, Auditory,Evoked Response, Auditory,Evoked Responses, Auditory,Potentials, Auditory Evoked
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000369	Aged, 80 and over	Persons 80 years of age and older.	Oldest Old