-transparent.png){kind=logo}
The uptake of bilirubin diglucuronide (BDG) into isolated rat hepatocytes was investigated in order to characterize the mechanism by which bile pigments are transported by the liver. The BDG uptake by hepatocytes was saturable. The uptake was inhibited by bilirubin, sulfobromophthalein, and bilirubin monoglucuronide, but not by taurocholate. The uptake was not affected by replacement of sodium with other cations except for choline. Only when sodium was replaced with choline, was significant decrease in uptake observed. When chloride was replaced with nitrate, BDG uptake decreased, but it was not changed by replacement with sulfate. Metabolic inhibitors did not affect BDG uptake significantly. Thus bile pigments share a common sodium-independent and electrogenic potential-dependent transporter in liver cell membranes. A high concentration of albumin interferes with BDG uptake.
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
January 1979,
The American journal of physiology,
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
October 1995,
Toxicology in vitro : an international journal published in association with BIBRA,
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
April 1984,
The Journal of pharmacology and experimental therapeutics,
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
December 1999,
FEBS letters,
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
September 1980,
Toxicology and applied pharmacology,
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
February 1981,
Biochimica et biophysica acta,
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
July 1979,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
March 1993,
Biological & pharmaceutical bulletin,
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
January 1981,
Drug metabolism and disposition: the biological fate of chemicals,
Y Adachi, and
R Kinne, and
J R Chowdhury, and
N R Chowdhury, and
L Theilmann, and
T Tran, and
I M Arias
January 1985,
Annals of the New York Academy of Sciences,
