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The placental passage and the the therapeutic efficacy of flomoxef (FMOX, 6315-S) were studied in patients in the perinatal period. A summary of the obtained results is as follows: 1. Concentrations of FMOX in maternal serum, umbilical cord serum and amniotic fluid obtained upon one-shot intravenous injections to 12 patients were compared with those obtained upon 1 hour drip infusions to 9 patients. It was found that the former means of administration gave higher concentrations that the latter. 2. Concentrations of FMOX in maternal serum, umbilical cord serum and amniotic fluid at 1 to 6 hours after administration through either method were all higher than MIC80's of recognized bacteria. 3. Clinical efficacies were evaluated in 10 patients with puerperal intrauterine infection, 7 patients with endometritis, 2 patients with pyelonephritis and 1 patient each with endo-cervicitis, amniotic fluid infection, mastitis and perineal wound infection. Clinical efficacies were excellent in 5 patients (21.7%), good in 17 patients (73.9%) and poor in 1 patient (4.4%), thus the overall efficacy rate was 95.7%. 4. Eradication of causative bacteria were obtained in all 8 cases tested, hence the eradication rate was 100%. 5. Mild diarrhea in 1 patient was the only side effect observed. No abnormal clinical laboratory test results were found in any patients.
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
June 1991,
The Japanese journal of antibiotics,
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
June 1991,
The Japanese journal of antibiotics,
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
June 1991,
The Japanese journal of antibiotics,
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
June 1991,
The Japanese journal of antibiotics,
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
June 1991,
The Japanese journal of antibiotics,
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
June 1991,
The Japanese journal of antibiotics,
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
June 1991,
The Japanese journal of antibiotics,
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
July 1993,
The Japanese journal of antibiotics,
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
September 1986,
The Japanese journal of antibiotics,
K Tamate, and
K Sengoku, and
M Ishikawa, and
T Shimizu, and
H Haga, and
T Hasegawa, and
H Takada, and
K Mure, and
M Kawamura, and
Y Torii
February 1988,
The Japanese journal of antibiotics,
