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Plasma catecholamines and their metabolites were sampled in 13 medication-free patients with obsessive-compulsive disorder (OCD) and 29 normal controls. In addition to severe OCD symptoms, the patients had significantly higher anxiety, tension, and resting pulse rates than the controls. Nonetheless, mean plasma concentrations of norepinephrine (NE) and epinephrine (E), the catecholamine metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA), and the stress-related hormone cortisol did not differ between OCD patients and normal controls. When the patients and control populations were combined and average plasma NE and E levels calculated over 35 min, subjects with a higher mean NE output (greater than 1.1 pm/ml) had higher Profile of Mood States depression scores than subjects with a low NE output (less than 1.1 pm/ml). Altogether, these results indicate that elevated plasma catecholamine measures are not likely to be associated with the pathophysiology of OCD.
C Benkelfat, and
I N Mefford, and
C F Masters, and
T E Nordahl, and
A C King, and
R M Cohen, and
D L Murphy
August 2016,
Psychiatry research. Neuroimaging,
C Benkelfat, and
I N Mefford, and
C F Masters, and
T E Nordahl, and
A C King, and
R M Cohen, and
D L Murphy
June 2011,
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists,
C Benkelfat, and
I N Mefford, and
C F Masters, and
T E Nordahl, and
A C King, and
R M Cohen, and
D L Murphy
January 1997,
Comprehensive psychiatry,
C Benkelfat, and
I N Mefford, and
C F Masters, and
T E Nordahl, and
A C King, and
R M Cohen, and
D L Murphy
October 2009,
Journal of affective disorders,
C Benkelfat, and
I N Mefford, and
C F Masters, and
T E Nordahl, and
A C King, and
R M Cohen, and
D L Murphy
November 1987,
Psychiatric journal of the University of Ottawa : Revue de psychiatrie de l'Universite d'Ottawa,
C Benkelfat, and
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October 1992,
The Journal of clinical psychiatry,
C Benkelfat, and
I N Mefford, and
C F Masters, and
T E Nordahl, and
A C King, and
R M Cohen, and
D L Murphy
January 2020,
Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law,
C Benkelfat, and
I N Mefford, and
C F Masters, and
T E Nordahl, and
A C King, and
R M Cohen, and
D L Murphy
January 1993,
Psychosomatics,
C Benkelfat, and
I N Mefford, and
C F Masters, and
T E Nordahl, and
A C King, and
R M Cohen, and
D L Murphy
January 1992,
New directions for mental health services,
C Benkelfat, and
I N Mefford, and
C F Masters, and
T E Nordahl, and
A C King, and
R M Cohen, and
D L Murphy
July 1992,
Hospital & community psychiatry,
