The loss of teeth, which is a frequent occurrence, is followed by functional, aesthetic and psychological problems. Dentistry has very important role to enable adequate rehabilitation as soon as possible. Removable dentures or fixed bridges on dental implants are most modern and best mode of rehabilitation for the patient. The advantages of implant anchored tooth restorations compared with classical procedures are multiple. Among others, there is prevention of bone resorption, correction of the stability and retention of the restorations, elimination of the preparation of adjacent teeth, as well as the improvement of the patient's psychological status. In order to achieve successful implantation, the following principles have to be taken into consideration: indications and contraindications; biocompatibility; osseointegration; the protocol of implant loading and the assessment of implant success. One of the biggest challenges is implantology under unfavourable anatomical conditions, as well as the implantation on irradiated tissue. However, these conditions are not absolute contraindications for implantation. The adequate choice of adequate implantological system enables successful implantation under different conditions.