Quercetin and interferon-beta modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients. 2008

Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY 14223 , United States. zs2@buffalo.edu

The study is aimed to determine the role of quercetin (3,3'4',5,7-pentahydroxy flavone), alone and in combination with human interferon-beta (IFN-beta), in modulating the immune response(s) of peripheral blood mononuclear cells (PBMC) isolated from multiple sclerosis (MS) patients and from normal healthy subjects. PBMC proliferation in the presence or absence of these drugs was determined and the production of proinflammatory cytokines (IL-1beta, TNF-alpha), and the ratio of cell migration mediator MMP-9, and its inhibitor, TIMP-1 were assessed in the culture supernatants. Quercetin reduced, in a dose-dependent manner, the proliferation of PBMC and modulated the level of IL-1beta and TNF-alpha released by PBMC in the culture supernatants. Quercetin reduced the MMP-9/TIMP-1 ratio via lowering MMP-9 production. Quercetin, when combined with IFN-beta, had additive effects in modulating TNF-alpha and MMP-9. These immunomodulatory responses to quercetin were similar between MS patients and healthy control (HC) subjects.

UI MeSH Term Description Entries
D007155 Immunologic Factors Biologically active substances whose activities affect or play a role in the functioning of the immune system. Biological Response Modifier,Biomodulator,Immune Factor,Immunological Factor,Immunomodulator,Immunomodulators,Biological Response Modifiers,Biomodulators,Factors, Immunologic,Immune Factors,Immunological Factors,Modifiers, Biological Response,Response Modifiers, Biological,Factor, Immune,Factor, Immunological,Factors, Immune,Factors, Immunological,Modifier, Biological Response,Response Modifier, Biological
D007963 Leukocytes, Mononuclear Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules. Mononuclear Leukocyte,Mononuclear Leukocytes,PBMC Peripheral Blood Mononuclear Cells,Peripheral Blood Human Mononuclear Cells,Peripheral Blood Mononuclear Cell,Peripheral Blood Mononuclear Cells,Leukocyte, Mononuclear
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009103 Multiple Sclerosis An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D011794 Quercetin A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. 3,3',4',5,7-Pentahydroxyflavone,Dikvertin
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
July 2007, Journal of the neurological sciences,
Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
July 2008, Journal of neuroimmunology,
Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
August 2000, Archives of neurology,
Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
May 2005, Journal of neuroimmunology,
Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
November 2018, Journal of neuroimmunology,
Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
January 2020, Cell stress & chaperones,
Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
April 1996, Multiple sclerosis (Houndmills, Basingstoke, England),
Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
August 2013, Journal of neuroimmunology,
Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
March 2018, Journal of neuroinflammation,
Zohara Sternberg, and Kailash Chadha, and Alicia Lieberman, and David Hojnacki, and Allison Drake, and Paolo Zamboni, and Paluch Rocco, and Erica Grazioli, and Bianca Weinstock-Guttman, and Frederick Munschauer
November 2022, Biology,
Copied contents to your clipboard!