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The anticaries effect of professional fluoride (F) application has been attributed to calcium-fluoride-like deposits (CaF(2)) formed on enamel, but this has not been clearly demonstrated. We hypothesized that CaF(2) formed on plaque-free enamel by F application would reduce enamel demineralization due to the increase of F availability in fluid of subsequently formed plaque. We created distinct levels of CaF(2) on enamel to evaluate a dose-response effect. Enamel blocks were mounted in contact with a S. mutans test plaque and used in situ by 10 volunteers. F released to the fluid phase of this substrate ("plaque fluid") was measured before a cariogenic challenge. "Plaque fluid" F concentration was highly correlated to the enamel CaF(2) concentration (r = 0.96, p < 0.001) and to consequent enamel demineralization (r = -0.75, p < 0.001). The results suggest that F released to plaque fluid from CaF(2) formed on enamel may play a significant role in the anticaries effect of professionally applied F agents.
L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
January 2020,
Journal of International Society of Preventive & Community Dentistry,
L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
January 2015,
Brazilian oral research,
L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
February 2001,
American journal of dentistry,
L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
September 2023,
Cureus,
L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
January 2015,
Brazilian oral research,
L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
June 2006,
BMC oral health,
L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
September 2001,
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L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
May 1981,
American journal of orthodontics,
L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
January 1988,
Operative dentistry,
L M A Tenuta, and
R V Cerezetti, and
A A Del Bel Cury, and
C P M Tabchoury, and
J A Cury
January 2009,
Caries research,
