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Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha. 2008
Keisuke Tachibana, and
Naohiko Anzai, and
Chihiro Ueda, and
Tatsuya Katayama, and
Daisuke Yamasaki, and
Takayoshi Kirino, and
Rika Takahashi, and
Kenji Ishimoto, and
Hidenori Komori, and
Toshiya Tanaka, and
Takao Hamakubo, and
Yukihiko Ueda, and
Hiroyuki Arai, and
Juro Sakai, and
Tatsuhiko Kodama, and
Takefumi Doi
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Although PDZK1 is a well-known adaptor protein, the mechanisms for its role in transcriptional regulation are largely unknown. The peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor that plays an important role in the regulation of lipid homeostasis. Previously, we established a tetracycline-regulated human cell line that can be induced to express PPARalpha and identified candidate target genes, one of which was PDZK1. In this study, we cloned and characterized the promoter region of the human pdzk1 gene and determined the PPAR response element. Finally, we demonstrate that endogenous PPARalpha regulates PDZK1 expression.
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